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. 2019 Dec 18;9:19380. doi: 10.1038/s41598-019-55919-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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TS_DIFF values and indication of statistically significant deviations from the null model based of a false discovery rate (FDR) of 0.05⁵³. Pale red cells are cells with a non-significantly lower number of observations than expected at random, and pale blue cells non-significantly higher numbers of observations. Dark red cells indicate significantly lower numbers of observations. Dark blue cells indicate significantly higher numbers of observations.