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. 2019 Dec 18;9:19406. doi: 10.1038/s41598-019-55866-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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H&E staining of the mouse corneas. Normal epithelium was observed in wild-type Ppip5k2^+/+ littermate controls (A,B). Thickened corneal epithelium layer was observed in some Ppip5k2^{+/K^} heterozygous (C) and Ppip5k2^{K^/K^} homozygous (E) mouse corneas. These corneas (C,E) were found to have irregular anterior corneal surfaces using SD-OCT scanning. Normal corneal epithelium thickness was noticed in other Ppip5k2^{+/K^} heterozygous (D) and Ppip5k2^{K^/K^} homozygous (F) mouse corneas. These corneas (D,F) were found to have no irregular anterior corneal surfaces using OCT scanning at 3 months of age. The black arrows showed the thickened epithelium in panels C and E. Abbreviations: Ep for epithelium, St for stroma, and End for endothelium of the mouse cornea.