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. Author manuscript; available in PMC: 2021 Apr 1.
Published in final edited form as: Shock. 2020 Apr;53(4):476–484. doi: 10.1097/SHK.0000000000001394

Figure 2: ER stress is primarily induced via alpha-adrenergic receptors in HepG2 cells.

Figure 2:

A) Representative immunofluorescence staining and quantification of BiP in HepG2 cells treated with 100 μM norepinephrine and the alpha-1, alpha-2, and beta-blocker (100 μM) (prazosin, yohimbine and propranolol, respectively) for 24 hours. B) Western blot and quantification showing the expression of BiP in response to the treatments indicated. NE, Norepinephrine. Arrows indicate positive cells. Experiments were repeated 3 separate times with a total sample size (n=8–9) per group included in the analysis. *p<0.05 vs NE or CTL respectively.