Skip to main content
. Author manuscript; available in PMC: 2021 Apr 1.
Published in final edited form as: Shock. 2020 Apr;53(4):476–484. doi: 10.1097/SHK.0000000000001394

Figure 4: Norepinephrine does not induce CHOP and apoptosis.

Figure 4:

A) Immunostaining of CHOP (Green) in HepG2 cells treated for 24 hours with norepinephrine (NE, 100 μM) or Thapsigargin (1.5 μM). Arrows indicate CHOP-positive cells. B) TUNEL assay was performed on HepG2 cells treated in the same conditions described in A). Arrows indicate TUNEL-positive cells. C) Averaged relative levels of cGMP in HepG2 treated with norepinephrine (100 μM) alone or in presence of the alpha- and beta-blockers (100 μM) for 24 hours. Experiments were repeated 3 separate times with a total sample size (n=9) per group included in the analysis.** p<0.01, *** p<0.001 vs CTL. ND, Not detected.