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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Semin Immunol. 2019 Apr;42:101305. doi: 10.1016/j.smim.2019.101305

Figure 1: LAG3 Structure and Ligands.

Figure 1:

LAG3 is composed of four Ig-like domains and contains three highly conserved regions in the cytoplasmic tail. LAG3 binds MHC class II through a thirty amino acid loop in the D1 domain. Galectin-3, LSECtin and FGL1 have also be reported to bind to LAG3.