Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Oct 11;24(1):1549–1564. doi: 10.1080/10717544.2017.1386729

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 7. — Activation of mitochondria-dependent apoptosis pathway and inhibition of EGFR-mediated PI3K/AKT and Ras/Raf/MEK/ERK pathways by GE11-Ori-Se NPs. (A) Effects of GE11-Ori-Se NPs, and the same dosage of oridonin or Chi-Se NPs on the production of ROS in KYSE-150 cells, n = 3. (B) Western blot analysis for the expression of Bcl-2 and Bax in KYSE-150 cells after GE11-Ori-Se NPs treatment. β-Actin was used as loading control. (C) Effects of GE11-Ori-Se NPs on the caspase-3 and caspase-9 activity in KYSE-150 cells, n = 3,**p < .01, ***p < .001. (D) Western bolt analysis for the expression of EGFR, p-EGFR, PI3K, p-PI3K, AKT, and p-AKT after GE11-Ori-Se NPs treatment. (E) Western bolt analysis for the expression of Ras, Raf, MEK, p-MEK, ERK, and p-ERK after GE11-Ori-Se NPs treatment. β-Actin was used as loading control. (F) The main signaling pathway of GE11-Ori-Se NPs-induced apoptosis.