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. 2019 Nov 12;11(11):600. doi: 10.3390/pharmaceutics11110600

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) Evaluation of luciferase knockdown efficacies of P5Y/siRNA complexes for in vivo use, in stably expressing HCT116-Luc cells over a range of different siRNA concentrations as indicated in the figure. (B) Luciferase activity of lysed HCT116-Luc tumors after in vivo treatment with P5Y/siRNA complexes. Bars represent the luciferase activities normalized for total protein concentrations from individual tumors of siCtrl-treated (blue) and siLuc-treated (red) mice.