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. 2019 Nov 12;11(11):600. doi: 10.3390/pharmaceutics11110600

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) Determination of blood serum markers for hepatotoxicity, cardiac or skeletal muscle damage, and kidney dysfunction. Healthy mice were repeatedly i.p. injected with P5Y/siCtrl complexes and blood serum levels were compared to untreated mice. ALAT: Alanine aminotransferase; ASAT: Aspartate aminotransferase; Gluc: Glucose; Alb: Albumin; LDH: Lactate deghydrogenase. (B) Absence of immunostimulation of P5Y/siCtrl complexes. Complexes were i.v. injected into immunocompetent mice twice within 24 h and blood was collected 4 h after the last injection. Treatment with lipopolysaccharides (LPS) served as positive control. #, not significant.