Figure 3.
(A) Principle of immunoisolation by a microcapsule. The semipermeable membrane provides protection against macromolecules and cells of the immune system while allowing the diffusion of low molecular weight molecules such as oxygen, glucose, nutrients, and insulin. (B) Schematic of pancreatic islet microencapsulation within alginate microcapsules obtained by ionic cross-linking in a CaCl2 bath where droplets that are generated by an electrostatic droplet generator are gelled. (C) Layers structure of an alginate-poly-L-lysine-alginate (APA) microcapsule and, brightfield image of a microencapsulated pseudoislet generated from the rat insulinoma INS1E cell line. Scale bar: 100 μm.