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. 2019 Nov 5;9(11):698. doi: 10.3390/biom9110698

Table 2.

Phosphorus-bases inhibitors of AChE and BuChE.

graphic file with name biomolecules-09-00698-i002.jpg
Code X IC50 (EeAChE) [µM] IC50 (EqBuChE) [µM] Selectivity AChE/BuChE
5a [22] O 86.3 ± 4.9 9.84 ± 0.06 8.77
5b [25] S 9.16 ± 0.17 18.3 ± 1.0 0.50
5c − 66.37 ± 1.14 2.37 ± 0.01 28.00
5d O 48.13 ± 1.70 25.00 ± 0.30 1.93
5e S 63.48 ± 1.41 170.10 ± 13.58 0.37
3k 60.29 ± 2.39 199.53 ± 2.02 0.30
Rivastigmine 56.10 ± 1.41 38.40 ± 1.97 1.46

AChE and BuChE inhibition are expressed as the mean ± SD (n = three experiments). The lowest IC50 value for each enzyme is shown in bold.