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. 2019 Nov 17;11(11):617. doi: 10.3390/pharmaceutics11110617

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Biodistribution and therapeutic efficacy in BALB/c mice bearing C26 tumor after intravenous injection of PL-Dox-Ce6. (A) Time course of Ce6 and Dox concentrations in plasma, tumor, liver and heart after injection of PL-Dox-Ce6 (Ce6: 1.25 mg/kg and Dox: 5.87 mg/kg). Data are expressed as the mean ± standard deviation (S.D.) for each group (N = 3). (B) Therapeutical efficacy of PL-Dox-Ce6. After liposomal drug (Ce6: 1.75 mg/kg and Dox: 8.3 mg/kg) injection, light irradiation was applied onto the tumor at 2 h and 12 h, respectively. Left panel, tumor size; Middle panel, survival rate; Right panel, body weight. The results are represented as the mean ± S.D. for each group (N = 8).