Figure 5.

(A) Diagram of dual-effect liposome (PL-cDDP-Ce6) with cisplatin (cDDP) and Ce6 encapsulated in the interior and lipid bilayer, respectively. (B) In vitro cytotoxicity under the impact of different liposomal drugs. A375 cells were incubated with PL-Dox-Ce6, PL-cDDP, PL-Ce6, and the combination of PL-Ce6 and PL-cDDP. The concentration of Ce6 and cDDP is 0.5 and 1.12 mg/mL, respectively. After incubation for 2 h, cells were irradiated with light (0.1 J/cm²) and cell viability was determined by MTT assay 24 h after light irradiation (* p < 0.05). (C) Tumor growth control of PL-cDDP-Ce6 (Ce6: 1.75 mg/kg; cisplatin: 3.72 mg/kg). After drug injection, light irradiation (100 J/cm²) was given at 2 h and 12 h, respectively. Left panel, tumor size; Middle panel, survival rate; Right panel, body weight. The results are represented as the mean ± S.D. for each group (N = 5).