Table 3.
Antituberculosis and antiproliferative activities against M. tuberculosis and human cancer cell lines of OMS A (1), dehydroxy-OMS A (4), and demethoxy-OMS A (6). IC50: half maximal inhibitory concentration, MIC50: the lowest concentration of antibiotics at which 50% of the isolates were inhibited.
| MIC50 (nM) | IC50 (μM) | ||||||
|---|---|---|---|---|---|---|---|
| Cell Lines/Strain | Mycobacterium Tuberculosis mc2 6230 | A549 | HCT 116 |
MDA-MB-231 | SK-HEP-1 | SNU 638 |
MRC-5 |
| OMS A (1) | 29.3 | 11.26 | 10.91 | 14.90 | 14.41 | 13.27 | >50 |
| Dehydroxy-OMS A (4) | 4.9 | 29.87 | 25.10 | 27.26 | 33.26 | 29.38 | >50 |
| Demethoxy-OMS A (6) | 40.2 | 9.56 | 7.68 | 9.52 | 10.11 | 11.58 | >50 |
| Etoposide | - | 0.42 | 1.23 | 7.79 | 1.11 | 1.24 | 14.68 |
| Isoniazid (INH) | 142.9 | - | - | - | - | - | - |
| Ethambutol (EMB) | 2700 | - | - | - | - | - | - |