Table 4.
Comparative binding affinity of different ligands with receptors.
| S.No. | Receptor | Ligand | Binding Affinity (kcal/mol) |
|---|---|---|---|
| 1 | Epidermal Growth Factor Receptor Kinase | CVRACGAD Cyclosaplin |
−7.7 −6.8 |
| 2 | Vascular Endothelial Growth Factor r 2 Receptor Kinase |
Cilengitide Cyclosaplin |
−8.1 −7.8 |
| 3 | Protein Kinase B | RPRTSSF Cyclosaplin |
−7.5 −8.1 |
| 4 | p38 (Mitogen Activated Protein Kinase) | FWCS Cyclosaplin |
−8.9 −8.3 |
| 5 | PTEN | YSV Cyclosaplin |
−7.8 6.3 |
| 6 | Matrix metalloproteinase-2 (MMP-2) |
CTTHWGFTLC Cyclosaplin |
−7.8 −8.2 |
| 7 | Matrix metalloproteinase-9 (MMP-9) |
CRRHWGFEFC Cyclosaplin |
−8.4 −7.3 |
| 8 | Procaspase 3 | Cilengitide Cyclosaplin |
−8.1 −7.8 |
| 9 | Procaspase 7 | RGDS Cyclosaplin |
−6.8 −8.7 |
| 10 | Caspase 9 | RGDS Cyclosaplin |
−6.7 −8.9 |
| 11 | TRAIL | CKVILTHRC Cyclosaplin |
−6.4 −8.2 |
| 12 | SURVIVIN | AYACNTSTL Cyclosaplin |
−7.2 −7.4 |