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. 2019 Nov 11;11(11):595. doi: 10.3390/pharmaceutics11110595

Figure 1.

Figure 1

Correlation of fraction unbound in brain homogenate (fu,brain) and muscle homogenate (fu,muscle). Unbound brain and muscle concentrations were determined by means of equilibrium dialysis of compound spiked into tissue homogenate. Experiments were performed in triplicate. The compounds derive from 10 different research projects with a molecular weight (MW) range from 305 to 563, a clogP range from 0.7 to 5.2, a total polar surface area (TPSA) from 46 to 119, an H-acceptor range from 2 to 8, and a FSP3 range from 0.19 to 0.62. Data are listed in Supplement Table S1.