Figure 5.

Correlation of K_p,br/mu with in vitro efflux measured in MDCK-MDR1 cells for compounds of three research projects (N = 48). The in vitro assay was performed at compound concentration of 10 µM (A) or 1 µM (B). Form of the symbols indicates individual research projects. Solid line represents regression; blue area is the 2-fold error range, dashed lines are 3-fold error lines. Symbols represent average values (n = 2–3 for K_p,br/mu and n = 2 for in vitro efflux). Data are listed in Supplement Table S5.