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Comparison of brain partitioning data in rats from this study with literature data.
| Drug | Kp,uu,brain* (Literature) |
Kp,uu,brain(hom)** (This publication) |
Kp,br/mu (This publication) |
|---|---|---|---|
| Carbamazapine | 0.771 | 1.44 | |
| Dantrolene | 0.0297 | 0.061 | 0.19 |
| Quinidine | 0.026 | 0.0276 | 0.056 |
*: [11], Partition coefficient of unbound drug between brain and plasma (Kp,uu,brain) determined with brain slice method.; **: Kp,uu,brain determined with brain homogenate method.
