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KIR1–7 sequence alignment of the C-terminal mutation hotspot. Red: Mutations associated with aberrant trafficking; Green: Residues whose mutations are currently not related to impaired trafficking. Numbers at the right refer to the last amino-acid residue in the respective sequence shown. Conserved residues among all KIR members are shaded gray. Locations of the di-acidic ER exit, G-loop and the Golgi-Export signal sequence (see text) are indicated below the alignment.
