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KIR1–7 sequence alignment of the transmembrane domain 1 mutation hotspot. Red: mutations associated with aberrant trafficking; Green: residues whose mutations are currently not related to impaired trafficking. Numbers at the right refer to the last amino-acid residue in the respective sequence shown. Conserved residues among all KIR members are shaded gray. Location of the transmembrane domain 1 (orange) is indicated below the alignment.
