Table 1.
Evidence of relative abundance of gut bacterial genera isolated from stool and tissue samples of CRC patients.
| Gut bacteria | Author | Published Time | Enrolment Time | Country | Sample Type (S/Ta) | Cancer Type | Method |
|---|---|---|---|---|---|---|---|
| Increased Gut Bacteria | |||||||
| Acidaminobacter | Weir [85] | 2013 | - | USA | S | CRC | 16S rDNA Sequencing |
| Acidovorax | Sanapareddy [86] | 2012 | - | USA | T | CRA | 16S rDNA Sequencing |
| Actinomyces | Peters [87] | 2016 | 2012–2014 | USA | S | CRC/CRA | Pyrosequencing |
| Kasai [88] | 2015 | 2012–2013 | Japan | S | CRC/CRA | T-RFLP/NGS | |
| Akkermansia | Weir [85] | 2013 | - | USA | S | CRC | 16S rDNA Sequencing |
| Mira-Pascual [89] | 2015 | - | Spain | T | CRC/CRA | qPCR | |
| Alistipes | Feng [90] | 2015 | 2010–2012 | Austria | S | A-CRAb/CRC | Metagenomic Shotgun Sequencing |
| Wu [91] | 2013 | - | China | S | CRC | 16S rRNA Sequencing | |
| Atopobium | Vogtmann [92] | 2016 | 1985–1987 | USA | S | CRC | Whole-genome Shotgun Sequencing |
| Kasai [88] | 2015 | 2012–2013 | Japan | S | CRC/CRA | T-RFLP/NGS | |
| Ahn [93] | 2013 | 1985–1989 | USA | S | CRC | 16S rDNA Sequencing | |
| Anaerococcus | Chen [94] | 2012 | - | China | T | CRC | 16S rDNA Sequencing |
| Anaerotruncus | Chen [94] | 2012 | - | China | T | CRC | 16S rDNA Sequencing |
| Aquabacterium | Sanapareddy [86] | 2012 | - | USA | T | CRA | 16S rDNA Sequencing |
| Bacteriodes | Feng [90] | 2015 | 2010–2012 | Austria | S | A-CRA/CRC | Metagenomic Shotgun Sequencing |
| Sobhani [95] | 2011 | 2004–2006 | France | S | CRC | Pyrosequencing/qPCR | |
| Kasai [88] | 2015 | 2012–2013 | Japan | S | CRC/CRA | T-RFLP/NGS | |
| Xu [96] | 2017 | - | China | T | CRC/CRA | NGS | |
| Brim [97] | 2013 | - | USA | S | Colon polyps | 16S rRNA Sequencing/HITChip/Pyrosequencing | |
| Flemer [98] | 2015 | - | Ireland | S/T | CRC/Polyps | 16S rDNA Sequencing | |
| Wang [99] | 2012 | - | China | S | CRC | 16S rDNA Sequencing | |
| Wu [91] | 2013 | - | China | S | CRC | 16S rDNA Sequencing | |
| Chen [94] | 2012 | - | China | T | CRC | 16S rDNA Sequencing | |
| Drewes [37] | 2017 | - | Malaysia | T | CRC | 16S rDNA Sequencing | |
| Gao [100] | 2015 | - | China | T | CRC | 16S rDNA Sequencing | |
| Liang [101] | 2016 | - | China | S | CRC | duplex qPCR | |
| Nakatsu [27] | 2015 | 2011–2014 | China | T | CRC/CRA | qPCR | |
| Huipeng [102] | 2014 | - | China | T | Colon cancer | PCR/DGGE | |
| Bifidobacterium | Nugent [103] | 2014 | - | USA | T | CRA | qPCR |
| Bilophila | Feng [90] | 2015 | 2010–2012 | Austria | S | A-CRA/CRC | Metagenomic Shotgun Sequencing |
| Hale [104] | 2017 | 2001–2005 | USA | S | CRA | 16S rDNA Sequencing | |
| Hibberd [105] | 2017 | - | USA | T | Colon cancer | 16S rDNA Sequencing | |
| Yazici [106] | 2017 | 2011–2012 | USA | T | CRC | 16S rDNA Sequencing | |
| Blautia | Ai [107] | 2017 | 2012 | China | S | CRC/CRA | 16S rRNA Sequencing |
| Wu [91] | 2013 | - | China | S | CRC | 16S rRNA Sequencing | |
| Mira-Pascual [89] | 2015 | - | Spain | T | CRC/CRA | 16S rRNA Sequencing/qPCR | |
| Butyrivibrio | Dejea [108] | 2014 | - | USA | T | CRC/CRA | Pyrosequencing |
| Campylobacter | Xu [96] | 2017 | - | China | T | CRC/CRA | NGS |
| Wu [91] | 2013 | - | China | S | CRC | 16S rRNA Sequencing | |
| Zhang [109] | 2018 | 2014–2015 | China | S | CRC/A-CRA/BP c | 16S rRNA Sequencing | |
| Citrobacter | Weir [85] | 2013 | - | USA | S | CRC | 16S rDNA Sequencing |
| Cloacibacterium | Sanapareddy [86] | 2012 | - | USA | T | CRA | 16S rDNA Sequencing |
| Clostridium | Dejea [108] | 2014 | - | USA | T | CRC/CRA | Pyrosequencing |
| Hibberd [105] | 2017 | - | USA | T | Colon cancer | 16S rDNA Sequencing | |
| Zhang [109] | 2018 | 2014–2015 | China | S | CRC/A-CRA/BP | 16S rDNA Sequencing | |
| Scanlan [110] | 2008 | - | Ireland | S | Colon cancer | 16S rRNA Sequencing | |
| Allali [36] | 2018 | - | Morocco | S | CRC | 16S rDNA Sequencing | |
| Kasai [88] | 2015 | 2012–2013 | Japan | S | CRC/CRA | T-RFLP/NGS | |
| Fukugaiti [111] | 2015 | - | Brazil | S | CRC | qPCR | |
| Ohigashi [112] | 2013 | 2009–2010 | Japan | S | CRC | qPCR | |
| Xie [113] | 2017 | 2016 | China | S | CRA/CRC/A-CRC | PCR | |
| Liang [101] | 2016 | - | China | S | CRC | duplex qPCR | |
| Collinsella | Chen [94] | 2012 | - | China | T | CRC | 16S rDNA Sequencing |
| Desulfovibrio | Hale [104] | 2017 | 2001–2005 | USA | S | CRA | 16S rRNA Sequencing |
| Chen [94] | 2012 | - | China | T | CRC | 16S rDNA Sequencing | |
| Dialister | Xu [96] | 2017 | - | China | T | CRC/CRA | NGS |
| Zhang [109] | 2018 | 2014–2015 | China | S | CRC/A-CRA/BP | 16S rDNA Sequencing | |
| Hibberd [105] | 2017 | - | USA | T | Colon cancer | 16S rDNA Sequencing | |
| Dorea | Peters [87] | 2016 | 2012–2014 | USA | S | CRC/CRA | Pyrosequencing |
| Wu [91] | 2013 | - | China | S | CRC | 16S rRNA Sequencing | |
| Hibberd [105] | 2017 | - | USA | S | Colon cancer | 16S rRNA Sequencing | |
| Shen [114] | 2010 | - | USA | T | CRA | 16S rDNA Sequencing | |
| Eggerthella | Zhang [109] | 2018 | 2014–2015 | China | S | CRC/A-CRA/BP | 16S rDNA Sequencing |
| Enterococcus | Chen [115] | 2013 | 2010–2011 | China | S | A-CRA | Pyrosequencing |
| Wang [99] | 2012 | - | China | S | CRC | 16S rDNA Sequencing | |
| Balamurugan [39] | 2008 | - | India | S | CRC | Real-time PCR | |
| Escherichia | Feng [90] | 2015 | 2010–2012 | Austria | S | A-CRA/CRC | Metagenomic Shotgun Sequencing |
| Xu [96] | 2017 | - | China | T | CRC/CRA | NGS | |
| Mori [116] | 2018 | 2013–2015 | Italy | S | CRC/CRA | 16S rRNA Sequencing | |
| Wang [99] | 2012 | - | China | S | CRC | 16S rRNA Sequencing | |
| Wu [91] | 2013 | - | China | S | CRC | 16S rRNA Sequencing | |
| Goedert [117] | 2015 | - | USA | S | CRA | 16S rRNA Sequencing | |
| Yoon [118] | 2017 | - | Korea | T | CRC/CRA | 16S rDNA Sequencing | |
| Gao [100] | 2015 | - | China | T | CRC | 16S rDNA Sequencing | |
| Mira-Pascual [89] | 2015 | - | Spain | T | CRC/CRA | qPCR | |
| Kohoutova [44] | 2014 | - | UK | T | CRC/CRA | PCR | |
| Bonnet [119] | 2013 | 2007–2010 | France | T | Colon cancer | PCR | |
| Swidsinski [120] | 1998 | - | Austria | T | CRC/CRA | PCR | |
| Eubacterium | Chen [94] | 2012 | - | China | T | CRC | 16S rDNA Sequencing |
| Faecalibacterium | Sze [121] | 2017 | - | USA | S | CRC/A-CRA/CRA | 16S rDNA Sequencing |
| Shen [114] | 2010 | - | USA | T | CRA | 16S rRNA Sequencing | |
| Fastidiosipila | Wu [91] | 2013 | - | China | S | CRC | 16S rRNA Sequencing |
| Fastidiosipila | Wu [91] | 2013 | - | China | S | CRC | 16S rRNA Sequencing |
| Fusobacterium | Vogtmann [92] | 2016 | 1985–1987 | USA | S | CRC | Whole-genome Shotgun Sequencing |
| Feng [90] | 2015 | 2010–2012 | Austria | S | A-CRA/CRC | Metagenomic Shotgun Sequencing | |
| Yu [122] | 2015 | - | China | S | CRC | Metagenomic Sequencing | |
| Dejea [108] | 2014 | - | USA | T | CRC/CRA | Pyrosequencing | |
| Xu [96] | 2017 | - | China | T | CRC/CRA | NGS | |
| Deng [123] | 2018 | - | China | S | CRC | NGS | |
| Kasai [88] | 2015 | 2012–2013 | Japan | S | CRC/CRA | T-RFLP/ NGS | |
| Kostic [124] | 2012 | - | Spain | T | CRC | WGS/16S rDNA Sequencing/qPCR/FISH | |
| Allali [36] | 2018 | - | Morocco | S | CRC | 16S rDNA Sequencing | |
| Zackular [125] | 2014 | - | Michigan | S | CRC/CRA | 16S rDNA Sequencing | |
| Ahn [93] | 2013 | 1985–1989 | Washington | S | CRC | 16S rDNA Sequencing | |
| Sinha [16] | 2016 | 1985–1987 | USA | S | CRC | 16S rDNA Sequencing | |
| Flemer [98] | 2015 | - | Ireland | S/T | CRC/Polyps | 16S rDNA Sequencing | |
| Flemer [126] | 2017 | - | Ireland | S/T | CRC/Polyps | 16S rDNA Sequencing | |
| Zhang [109] | 2018 | 2014–2015 | China | S | CRC/A-CRA/BP | 16S rDNA Sequencing | |
| Zeller [28] | 2014 | 2004–2006 | France/Germany | S | CRC/CRA | 16S rDNA Sequencing | |
| Baxter [127] | 2016 | - | USA | S | CRC/CRA | 16S rDNA Sequencing | |
| Gao [100] | 2015 | - | China | T | CRC | 16S rDNA Sequencing | |
| Hibberd [105] | 2017 | - | USA | T | Colon cancer | 16S rDNA Sequencing | |
| Chen [94] | 2012 | - | China | T | CRC | 16S rDNA Sequencing | |
| Drewes [37] | 2017 | - | Malaysia | T | CRC | 16S rDNA Sequencing | |
| Yoon [118] | 2017 | - | Korea | T | CRC/CRA | 16S rDNA Sequencing | |
| Amitay [128] | 2017 | 2005–2013 | Germany | S | CRC/A-CRA/CRA | 16S rDNA Sequencing/multiplex PCR | |
| Nakatsu [27] | 2015 | 2011–2014 | China | T | CRC/CRA | 16S rRNA Sequencing/qPCR | |
| Wu [91] | 2013 | - | China | S | CRC | 16S rDNA Sequencing/qPCR | |
| Russo [129] | 2018 | 2015–2016 | Italy | S | CRC | qPCR/16S rDNA Sequencing | |
| Liang [101] | 2016 | - | China | S | CRC | duplex qPCR | |
| Kostic [60] | 2013 | - | USA | S | CRC/CRA | qPCR | |
| Wong [130] | 2016 | - | China | S | CRC/A-CRA | qPCR | |
| Fukugaiti [111] | 2015 | - | Brazil | S | CRC | qPCR | |
| Eklof [131] | 2017 | 2008–2013 | Sweden | S | CRC | qPCR | |
| Mira-Pascual [89] | 2015 | - | Spain | S | CRC/CRA | qPCR | |
| Yu [122] | 2015 | - | China | S | CRC | qPCR | |
| Flanagan [132] | 2014 | 2008–2010 | Ireland | S | CRC | qPCR | |
| Repass [133] | 2016 | - | USA | T | CRC | qPCR | |
| Castellarin [134] | 2012 | - | Canada | T | CRC | qPCR | |
| Tahara [135] | 2014 | - | Japan | T | CRC | qPCR | |
| Ito [136] | 2015 | 2001–2013 | Japan | T | CRC | qPCR | |
| McCoy [137] | 2013 | - | USA | T | CRA | qPCR | |
| Suehiro [138] | 2016 | - | Japan | S | CRC/CRA/A-CRA | PCR | |
| Gemella | Zhang [109] | 2018 | 2014 - 2015 | China | S | CRC/A-CRA/BP | 16S rDNA Sequencing |
| Baxter [127] | 2016 | - | USA | S | CRC/CRA | 16S rDNA Sequencing | |
| Chen [94] | 2012 | - | China | T | CRC | 16S rDNA Sequencing | |
| Nakatsu [27] | 2015 | 2011–2014 | China | T | CRC/CRA | 16S rRNA Sequencing/qPCR | |
| Granulicatella | Nakatsu [27] | 2015 | 2011–2014 | China | T | CRC/CRA | 16S rRNA Sequencing/qPCR |
| Heamophilus | Kasai [88] | 2015 | 2012–2013 | Japan | S | CRC/CRA | T-RFLP/NGS |
| Helicobacter | Goedert [117] | 2015 | - | USA | S | CRA | 16S rRNA Sequencing |
| Sanapareddy [86] | 2012 | - | USA | T | CRA | 16S rDNA Sequencing | |
| Klebsiella | Wang [99] | 2012 | - | China | S | CRC | 16S rDNA Sequencing |
| Goedert [117] | 2015 | - | USA | S | CRA | 16S rRNA Sequencing | |
| Chen [94] | 2012 | - | China | T | CRC | 16S rDNA Sequencing | |
| Lactobacillus | Xu [96] | 2017 | - | China | T | CRC/CRA | NGS |
| Sanapareddy [86] | 2012 | - | USA | T | CRA | 16S rDNA Sequencing | |
| Lactococcus | Lu [139] | 2016 | 2014 | China | T | CRA | Pyrosequencing |
| Sanapareddy [86] | 2012 | - | USA | T | CRA | 16S rDNA Sequencing | |
| Gao [100] | 2015 | - | China | T | CRC | 16S rDNA Sequencing | |
| Methanobrevibacter | Hibberd [105] Mira-Pascual [89] | 2017 | - | USA | T | Colon cancer CRC/CRA | 16S rDNA Sequencing |
| 2015 | - | Spain | S | qPCR | |||
| Methanosphaera | Ai [107] | 2017 | 2012 | China | S | CRC/CRA | 16S rRNA Sequencing |
| Mogibacterium | Xu [96] | 2017 | - | China | T | CRC/CRA | NGS |
| Hale [104] | 2017 | 2001–2005 | USA | S | CRA | 16S rRNA Sequencing | |
| Chen [94] | 2012 | - | China | T | CRC | 16S rDNA Sequencing | |
| Morganella | Goedert [117] | 2015 | - | USA | S | CRA | 16S rRNA Sequencing |
| Odoribacter | Wu [91] | 2013 | - | China | S | CRC | 16S rRNA Sequencing |
| Oscillibacter | Wu [91] | 2013 | - | China | S | CRC | 16S rRNA Sequencing |
| Flemer [98] | 2015 | - | Ireland | S/T | CRC/Polyps | 16S rRNA Sequencing | |
| Oscillospira | Deng [123] | 2018 | - | China | S | CRC | NGS |
| Pantoea | Goedert [117] | 2015 | - | USA | S | CRA | 16S rRNA Sequencing |
| Parabacteroides | Feng [90] | 2015 | 2010–2012 | Austria | S | A-CRA/CRC | Metagenomic Shotgun Sequencing |
| Parvimonas | Feng [90] | 2015 | 2010–2012 | Austria | S | A-CRA/CRC | Metagenomic Shotgun Sequencing |
| Yu [122] | 2015 | - | China | S | CRC | Metagenomic Sequencing | |
| Xu [96] | 2017 | - | China | T | CRC/CRA | NGS | |
| Zhang [109] | 2018 | 2014–2015 | China | S | CRC/A-CRA/BP | 16S rDNA Sequencing | |
| Baxter [127] | 2016 | - | USA | S | CRC/CRA | 16S rRNA Sequencing | |
| Flemer [98] | 2015 | - | Ireland | S/T | CRC/Polyps | 16S rDNA Sequencing | |
| Flemer [126] | 2017 | - | Ireland | S/T | CRC/Polyps | 16S rDNA Sequencing | |
| Sze [121] | 2017 | - | USA | S | CRC/A-CRA/CRA | 16S rDNA Sequencing | |
| Drewes [37] | 2017 | - | Malaysia | T | CRC | 16S rDNA Sequencing | |
| Nakatsu [27] | 2015 | 2011–2014 | China | T | CRC/CRA | 16S rRNA Sequencing /qPCR | |
| Wong [130] | 2016 | - | China | S | CRC/A-CRA | qPCR | |
| Peptostreptococcus | Yu [122] | 2015 | - | China | S | CRC | Metagenomic Sequencing |
| Xu [96] | 2017 | - | China | T | CRC/CRA | NGS | |
| Zhang [109] | 2018 | 2014–2015 | China | S | CRC/A-CRA/BP | 16S rDNA Sequencing | |
| Baxter [127] | 2016 | - | USA | S | CRC/CRA | 16S rRNA Sequencing | |
| Zeller [28] | 2014 | 2004–2006 | France/Germany | S | CRC/CRA | 16S rRNA Sequencing | |
| Flemer [98] | 2015 | - | Ireland | S/T | CRC/Polyps | 16S rRNA Sequencing | |
| Flemer [126] | 2017 | - | Ireland | S/T | CRC/Polyps | 16S rRNA Sequencing | |
| Hibberd [105] | 2017 | - | USA | S/T | Colon cancer | 16S rRNA Sequencing | |
| Chen [94] | 2012 | - | China | T | CRC | 16S rDNA Sequencing | |
| Drewes [37] | 2017 | - | Malaysia | T | CRC | 16S rDNA Sequencing | |
| Gao [100] | 2015 | - | China | T | CRC | 16S rDNA Sequencing | |
| Wang [99] | 2012 | - | China | S | CRC | 16S rDNA Sequencing/qPCR | |
| Nakatsu [27] | 2015 | 2011–2014 | China | T | CRC/CRA | 16S rRNA Sequencing/qPCR | |
| Phascolarctobacterium | Weir [85] | 2013 | - | USA | S | CRC | 16S rDNA Sequencing |
| Wu [91] | 2013 | - | China | S | CRC | 16S rDNA Sequencing | |
| Porphyromonas | Vogtmann [92] | 2016 | 1985–1987 | USA | S | CRC | Whole-genome Shotgun Sequencing |
| Sobhani [95] | 2011 | 2004–2006 | France | S | CRC | Pyrosequencing/qPCR | |
| Baxter [127] | 2016 | - | USA | S | CRC/CRA | 16S rRNA Sequencing | |
| Allali [36] | 2018 | - | Morocco | S | CRC | 16S rRNA Sequencing | |
| Zackular [125] | 2014 | - | Michigan | S | CRC/CRA | 16S rRNA Sequencing | |
| Sze [121] | 2017 | - | USA | S | CRC/A-CRA/CRA | 16S rRNA Sequencing | |
| Ahn [93] | 2013 | 1985–1989 | Washington | S | CRC | 16S rRNA Sequencing | |
| Wang [99] | 2012 | - | China | S | CRC | 16S rRNA Sequencing | |
| Sinha [16] | 2016 | 1985–1987 | USA | S | CRC | 16S rRNA Sequencing | |
| Zhang [109] | 2018 | 2014–2015 | China | S | CRC/A-CRA/BP | 16S rRNA Sequencing | |
| Zeller [28] | 2014 | 2004–2006 | France/Germany | S | CRC/CRA | 16S rRNA Sequencing | |
| Flemer [98] | 2015 | - | Ireland | S/T | CRC/Polyps | 16S rRNA Sequencing | |
| Chen [94] | 2012 | - | China | T | CRC | 16S rDNA Sequencing | |
| Geng [140] | 2014 | - | China | T | CRC/CRA | 16S rRNA Sequencing | |
| Prevotella | Deng [123] | 2018 | - | China | S | CRC | NGS |
| Kasai [88] | 2015 | 2012–2013 | Japan | S | CRC/CRA | T-RFLP/NGS | |
| Baxter [127] | 2016 | - | USA | S | CRC/CRA | 16S rRNA Sequencing | |
| Flemer [126] | 2017 | - | Ireland | S/T | CRC/Polyps | 16S rRNA Sequencing | |
| Gao [100] | 2015 | - | China | T | CRC | 16S rDNA Sequencing | |
| Chen [94] | 2012 | - | China | T | CRC | 16S rDNA Sequencing | |
| Mira-Pascual [89] | 2015 | - | Spain | T | CRC/CRA | 16S rRNA Sequencing/qPCR | |
| Paraprevotella | Chen [94] | 2012 | - | China | T | CRC | 16S rDNA Sequencing |
| Pseudomonas | Lu [139] | 2016 | 2014 | China | T | CRA | Pyrosequencing |
| Zackular [125] | 2014 | - | Michigan | S | CRC/CRA | 16S rDNA Sequencing | |
| Goedert [117] | 2015 | - | USA | S | CRA | 16S rRNA Sequencing | |
| Sanapareddy [86] | 2012 | - | USA | T | CRA | 16S rDNA Sequencing | |
| Yoon [118] | 2017 | - | Korea | T | CRC/CRA | 16S rDNA Sequencing | |
| Ohigashi [112] | 2013 | 2009–2010 | Japan | S | CRC | qPCR | |
| Pyramidobacter | Yazici [106] | 2017 | 2011–2012 | USA | T | CRC | 16S rRNA Sequencing |
| Rhizobium | Yoon [118] | 2017 | - | Korea | T | CRC/CRA | 16S rDNA Sequencing |
| Roseburia | Flemer [98] | 2015 | - | Ireland | S/T | CRC/Polyps | 16S rDNA Sequencing |
| Liang [101] | 2016 | - | China | S | CRC | duplex qPCR | |
| Ruminococcus | Dejea [108] | 2014 | - | USA | T | CRC/CRA | Pyrosequencing |
| Allali [36] | 2018 | - | Morocco | S | CRC | 16S rDNA Sequencing | |
| Zhang [109] | 2018 | 2014–2015 | China | S | CRC/A-CRA/BP CRC/Polyps | 16S rDNA Sequencing | |
| Flemer [98] | 2015 | - | Ireland | S/T | CRA | 16S rDNA Sequencing | |
| Shen [114] | 2010 | - | USA | T | 16S rRNA Sequencing | ||
| Salmonella | Goedert [117] | 2015 | - | USA | S | CRA | 16S rRNA Sequencing |
| Selenomonas | Allali [36] | 2018 | - | Morocco | S | CRC | 16S rDNA Sequencing |
| Hibberd [105] | 2017 | - | USA | T | Colon cancer | 16S rDNA Sequencing | |
| Serratia | Goedert [117] | 2015 | - | USA | S | CRA | 16S rDNA Sequencing |
| Slackia | Chen [94] | 2012 | - | China | T | CRC | 16S rDNA Sequencing |
| Sphingomonas | Richard [141] | 2018 | - | France | T | CACd/CRC | qPCR/16S rRNA Sequencing |
| Shigella | Goedert [117] | 2015 | - | USA | S | CRA | 16S rDNA Sequencing |
| Mori [116] | 2018 | 2013–2015 | Italy | S | CRC/CRA | 16S rRNA Sequencing | |
| Wang [99] | 2012 | - | China | S | CRC | 16S rRNA Sequencing | |
| Wu [91] | 2013 | - | China | S | CRC | 16S rRNA Sequencing | |
| Shen [114] | 2010 | - | USA | T | CRA | 16S rRNA Sequencing | |
| Gao [100] | 2015 | - | China | T | CRC | 16S rDNA Sequencing | |
| Mira-Pascual [89] | 2015 | - | Spain | T | CRC/CRA | qPCR | |
| Solobacterium | Yu [122] | 2015 | - | China | S | CRC | Metagenomic Sequencing |
| Zhang [109] | 2018 | 2014–2015 | China | S | CRC/A-CRA/BP | 16S rDNA Sequencing | |
| Streptococcus | Chen [115] | 2013 | 2010–2011 | China | S | A-CRA | Pyrosequencing |
| Peters [87] | 2016 | 2012–2014 | USA | S | CRC/CRA | Pyrosequencing | |
| Kasai [88] | 2015 | 2012–2013 | Japan | S | CRC/CRA | T-RFLP/NGS | |
| Flemer [126] | 2017 | - | Ireland | S/T | CRC/Polyps | 16S rDNA Sequencing | |
| Wang [99] | 2012 | - | China | S | CRC | 16S rDNA Sequencing | |
| Gao [100] | 2015 | - | China | T | CRC | 16S rDNA Sequencing | |
| Chen [94] | 2012 | - | China | T | CRC | 16S rDNA Sequencing | |
| Geng [140] | 2014 | - | China | T | CRC/CRA | 16S rRNA Sequencing | |
| Richard [141] | 2018 | - | France | T | CAC/CRC | qPCR/16S rRNA Sequencing | |
| Klein [82] | 1977 | - | Chicago | S | CRC | Culture | |
| Subdoligranulum | Wu [91] | 2013 | - | China | S | CRC | 16S rRNA Sequencing |
| Sutterella | Mori [116] | 2018 | 2013–2015 | Italy | S | CRC/CRA | 16S rRNA Sequencing |
| Hale [104] | 2017 | 2001–2005 | USA | S | CRA | 16S rRNA Sequencing | |
| Trabulsiella | Goedert [117] | 2015 | - | USA | S | CRA | 16S rRNA Sequencing |
| Veillonella | Kasai [88] | 2015 | 2012–2013 | Japan | S | CRC/CRA | T-RFLP/NGS |
| Geng [140] | 2014 | - | China | T | CRC/CRA | 16S rRNA Sequencing | |
| Decreased Gut Bacteria | |||||||
| Acidovorax | Gao [100] | 2015 | - | China | T | CRC | 16S rDNA Sequencing |
| Acinetobacter | Gao [100] | 2015 | - | China | T | CRC | 16S rDNA Sequencing |
| Alistipes | Wang [99] | 2012 | - | China | S | CRC | 16S rDNA Sequencing |
| Nakatsu [27] | 2015 | 2011–2014 | China | T | CRC/CRA | 16S rRNA Sequencing | |
| Anaerostipes | Chen [94] | 2012 | - | China | T | CRC | 16S rDNA Sequencing |
| Atopobium | Ohigashi [112] | 2013 | 2009–2010 | Japan | S | CRC | qPCR |
| Bacteriodes | Kostic [124] | 2012 | - | Spain | T | CRC | WGS |
| Zackular [125] | 2014 | - | Michigan | S | CRC/CRA | 16S rDNA Sequencing | |
| Wang [99] | 2012 | - | China | S | CRC | 16S rDNA Sequencing | |
| Weir [85] | 2013 | - | USA | S | CRC | 16S rDNA Sequencing | |
| Allali [36] | 2018 | - | Morocco | S | CRC | 16S rDNA Sequencing | |
| Shen [114] | 2010 | - | USA | T | CRA | 16S rDNA Sequencing | |
| Nakatsu [27] | 2015 | 2011–2014 | China | T | CRC/CRA | 16S rDNA Sequencing | |
| Ohigashi [112] | 2013 | 2009–2010 | Japan | S | CRC | qPCR | |
| Bacillus | Lu [139] | 2016 | 2014 | China | T | CRA | Pyrosequencing |
| Mira-Pascual [89] | 2015 | - | Spain | T | CRC/CRA | qPCR | |
| Bifidobacterium | Feng [90] | 2015 | 2010–2012 | Austria | S | A-CRA/CRC | Metagenomic Shotgun Sequencing |
| Chen [94] | 2012 | - | China | T | CRC | 16S rDNA Sequencing | |
| Mira-Pascual [89] | 2015 | - | Spain | S | CRC/CRA | qPCR | |
| Ohigashi [112] | 2013 | 2009–2010 | Japan | S | CRC | qPCR | |
| Yusuf [38] | 2016 | - | Indonesia | S | CRC | DGGE | |
| Blautia | Xu [96] | 2017 | - | China | T | CRC/CRA | NGS |
| Chen [94] | 2012 | 2011–2014 | China | T | CRC | 16S rDNA Sequencing | |
| Nakatsu [27] | 2015 | - | China | T | CRC/CRA | 16S rDNA Sequencing | |
| Gao [100] | 2015 | - | China | T | CRC | 16S rDNA Sequencing | |
| Buttiauxella | Gao [100] | 2015 | - | China | T | CRC | 16S rDNA Sequencing |
| Caulobacter | Gao [100] | 2015 | - | China | T | CRC | 16S rRNA Sequencing |
| Collinsella | Nakatsu [27] | 2015 | 2011–2014 | China | T | CRC/CRA | 16S rRNA Sequencing |
| Clostridium | Chen [115] | 2013 | 2010–2011 | China | S | A-CRA | Pyrosequencing |
| Zackular [125] | 2014 | - | Michigan | S | CRC/CRA | 16S rDNA Sequencing | |
| Ohigashi [112] | 2013 | 2009–2010 | Japan | S | CRC | qPCR | |
| Coprococcus | Vogtmann [92] | 2016 | 1985–1987 | USA | S | CRC | Whole-genome Shotgun Sequencing |
| Ahn [93] | 2013 | 1985–1989 | USA | S | CRC | 16S rDNA Sequencing | |
| Zhang [109] | 2018 | 2014–2015 | China | S | CRC/A-CRA/BP | 16S rDNA Sequencing | |
| Flemer [98] | 2015 | - | Ireland | S/T | CRC/Polyps | 16S rDNA Sequencing | |
| Shen [114] | 2010 | - | USA | T | CRA | 16S rRNA Sequencing | |
| Desulfovibrio | Scanlan [142] | 2009 | - | UK | S | CRC | qPCR |
| Dialister | Weir [85] | 2013 | - | USA | S | CRC | 16S rDNA Sequencing |
| Dorea | Weir [85] | 2013 | - | USA | S | CRC | 16S rDNA Sequencing |
| Enterococcus | Lu [139] | 2016 | 2014 | China | T | CRA | Pyrosequencing |
| Epilithonimonas | Gao [100] | 2015 | - | China | T | CRC | 16S rDNA Sequencing |
| Eubacterium | Yu [122] | 2015 | - | China | S | CRC | Metagenomic Sequencing |
| Chen [115] | 2013 | 2010–2011 | China | S | A-CRA | Pyrosequencing | |
| Kasai [88] | 2015 | 2012–2013 | Japan | S | CRC/CRA | T-RFLP/NGS | |
| Wang [99] | 2012 | - | China | S | CRC | 16S rDNA Sequencing | |
| Zhang [109] | 2018 | 2014–2015 | China | S | CRC/A-CRA/BP | 16S rDNA Sequencing | |
| Balamurugan [39] | 2008 | - | India | S | CRC | Real-time PCR | |
| Vargo [83] | 1980 | - | USA | S | Colon cancer | Culture | |
| Faecalibacterium | Xu [96] | 2017 | - | China | T | CRC/CRA | NGS |
| Wu [91] | 2013 | - | China | S | CRC | 16S rRNA Sequencing | |
| Chen [94] | 2012 | - | China | T | CRC | 16S rDNA Sequencing | |
| Nakatsu [27] | 2015 | 2011–2014 | China | T | CRC/CRA | 16S rRNA Sequencing | |
| Balamurugan [39] | 2008 | - | India | S | CRC | Real-time PCR | |
| Mira-Pascual [89] | 2015 | - | Spain | T | CRC/CRA | qPCR | |
| Lopez-Siles [143] | 2016 | - | Spain | T | CRC | qPCR | |
| Fusicatenibacter | Zhang [109] | 2018 | 2014–2015 | China | S | CRC/A-CRA/BP | 16S rDNA Sequencing |
| Flavobacterium | Gao [100] | 2015 | - | China | T | CRC | 16S rDNA Sequencing |
| Fusobacterium | Shen [114] | 2010 | - | USA | T | CRA | 16S rRNA Sequencing |
| Richard [141] | 2018 | - | France | T | CAC/CRC | qPCR/16S rRNA Sequencing | |
| Vargo [83] | 1980 | - | USA | S | Colon cancer | Culture | |
| Haemophilus | Hale [104] | 2017 | 2001–2005 | USA | S | CRA | 16S rRNA Sequencing |
| Janthinobacterium | Gao [100] | 2015 | - | China | T | CRC | 16S rDNA Sequencing |
| Lachnobacterium | Weir [85] | 2013 | - | USA | S | CRC | 16S rDNA Sequencing |
| Lachnospira | Weir [85] | 2013 | - | USA | S | CRC | 16S rDNA Sequencing |
| Chen [94] | 2012 | - | China | T | CRC | 16S rDNA Sequencing | |
| Lactobacillus | Feng [90] | 2015 | 2010–2012 | Austria | S | A-CRA/CRC | Metagenomic Shotgun Sequencing |
| Chen [94] | 2012 | - | China | T | CRC | 16S rDNA Sequencing | |
| Megamonas | Weir [85] | 2013 | - | USA | S | CRC | 16S rDNA Sequencing |
| Megasphaera | Ahn [93] | 2013 | 1985–1989 | Washington | S | CRC | 16S rDNA Sequencing |
| Parasutterella | Wang [99] | 2012 | - | China | S | CRC | 16S rDNA Sequencing |
| Pedobacter | Gao [100] | 2015 | - | China | T | CRC | 16S rDNA Sequencing |
| Propionibacterium | Gao [100] | 2015 | - | China | T | CRC | 16S rDNA Sequencing |
| Peptostreptococcus | Ahn [93] | 2013 | 1985–1989 | Washington | S | CRC | 16S rDNA Sequencing |
| Prevotella | Weir [85] | 2013 | - | USA | S | CRC | 16S rDNA Sequencing |
| Pseudobutyrivibrio | Weir [85] | 2013 | - | USA | S | CRC | 16S rDNA Sequencing |
| Chen [94] | 2012 | - | China | T | CRC | 16S rDNA Sequencing | |
| Pseudomonas | Gao [100] | 2015 | - | China | T | CRC | 16S rDNA Sequencing |
| Psychrobacter | Gao [100] | 2015 | - | China | T | CRC | 16S rDNA Sequencing |
| Rahnella | Gao [100] | 2015 | - | China | T | CRC | 16S rDNA Sequencing |
| Roseburia | Chen [115] | 2013 | 2010–2011 | China | S | A-CRA | Pyrosequencing |
| Wang [99] | 2012 | - | China | S | CRC | 16S rDNA Sequencing | |
| Wu [91] | 2013 | - | China | S | CRC | 16S rRNA Sequencing | |
| Hibberd [105] | 2017 | - | USA | S | Colon cancer | 16S rRNA Sequencing | |
| Zhang [109] | 2018 | 2014–2015 | China | S | CRC/A-CRA/BP | 16S rRNA Sequencing | |
| Chen [94] | 2012 | - | China | T | CRC | 16S rDNA Sequencing | |
| Ruminococcus | Feng [90] | 2015 | 2010–2012 | Austria | S | A-CRA/CRC | Metagenomic Shotgun Sequencing |
| Ahn [93] | 2013 | 1985–1989 | Washington | S | CRC | 16S rDNA Sequencing | |
| Weir [85] | 2013 | - | USA | S | CRC | 16S rDNA Sequencing | |
| Zhang [109] | 2018 | 2014–2015 | China | S | CRC/A-CRA/BP | 16S rDNA Sequencing | |
| Richard [141] | 2018 | - | France | T | CAC/CRC | qPCR/16S rRNA Sequencing | |
| Selenomonas | Ahn [93] | 2013 | 1985–1989 | Washington | S | CRC | 16S rDNA Sequencing |
| Slackia | Kasai [88] | 2015 | 2012–2013 | Japan | S | CRC/CRA | T-RFLP/NGS |
| Solibacillus | Lu [139] | 2016 | 2014 | China | T | CRA | Pyrosequencing |
| Sphingobacterium | Gao [100] | 2015 | - | China | T | CRC | 16S rDNA Sequencing |
| Sphingomonas | Gao [100] | 2015 | - | China | T | CRC | 16S rDNA Sequencing |
| Staphylococcus | Ohigashi [112] | 2013 | 2009–2010 | Japan | S | CRC | qPCR |
| Mira-Pascual [89] | 2015 | - | Spain | T | CRC/CRA | qPCR | |
| Streptococcus | Feng [90] | 2015 | 2010–2012 | Austria | S | A-CRA/CRC | Metagenomic Shotgun Sequencing |
| Hale [104] | 2017 | 2001–2005 | USA | S | CRA | 16S rRNA Sequencing | |
| Zhang [109] | 2018 | 2014–2015 | China | S | CRC/A-CRA/BP | 16S rDNA Sequencing | |
| Hibberd [105] | 2017 | - | USA | T | Colon cancer | 16S rDNA Sequencing | |
| Sanapareddy [86] | 2012 | - | USA | T | CRA | 16S rDNA Sequencing | |
| Stenotrophomonas | Gao [100] | 2015 | - | China | T | CRC | 16S rDNA Sequencing |
| Sutterella | Nakatsu [27] | 2015 | 2011–2014 | China | T | CRC/CRA | 16S rRNA Sequencing/qPCR |
| Veillonella | Hale [104] | 2017 | 2001–2005 | USA | S | CRA | 16S rRNA Sequencing |
a Stool/Tissue. b Advanced colorectal adenoma. c Benign polyp. d Colitis-associated cancer. Gut bacteria isolated from stool or tissue samples with both increased and decreased evidence are presented in bold.