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. 2019 Oct 31;9(11):675. doi: 10.3390/biom9110675

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The effect of the lysosomal sequestration of IM on Bcr-Abl signaling in SUN-stimulated cancer cells. SUN-stimulated cells were incubated with various TKIs concentration in the absence or presence BafA1. After 6 h, cell extracts were analyzed for the CrkL phosphorylation (Tyr207) and Bcr-Abl phosphorylation (Bcr (Tyr177)) using western blot analysis. (a) Cells incubated wit IM ± BafA1 (typical analysis). (b) Quantitative analysis of western blots using densitometry. (c) Cells incubated wit NIL ± BafA1 (typical analysis). (d) Quantitative analysis of western blots using densitometry. (e) Cells incubated wit DAS ± BafA1 (typical analysis). (f) Quantitative analysis of western blots using densitometry. Columns represent the means and standard deviations of four independent experiments.

The effect of the lysosomal sequestration of IM on Bcr-Abl signaling in SUN-stimulated cancer cells. SUN-stimulated cells were incubated with various TKIs concentration in the absence or presence BafA1. After 6 h, cell extracts were analyzed for the CrkL phosphorylation (Tyr207) and Bcr-Abl phosphorylation (Bcr (Tyr177)) using western blot analysis. (a) Cells incubated wit IM ± BafA1 (typical analysis). (b) Quantitative analysis of western blots using densitometry. (c) Cells incubated wit NIL ± BafA1 (typical analysis). (d) Quantitative analysis of western blots using densitometry. (e) Cells incubated wit DAS ± BafA1 (typical analysis). (f) Quantitative analysis of western blots using densitometry. Columns represent the means and standard deviations of four independent experiments.