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. 2019 Nov 8;9(11):719. doi: 10.3390/biom9110719

Figure 4.

Figure 4

Caffeine inhibits mitochondrial apoptosis in the LPS-injected mice: (a) Western blot results of BCL2-associated X, apoptosis regulator (Bax), B-cell lymphoma 2 (Bcl-2), and cleaved Caspase-3 in the brains of the experimental mice (n = 10 mice per group; number of experiments = 3; statistical analysis used was one-way ANOVA with Tukey’s posthoc test for comparisons among the different groups); (b) immunofluorescence images of cleaved Caspase-3 in the experimental groups, magnification 30×, scale bar 60 µm; * significantly different from the vehicle-treated control group, # significantly different from the LPS-treated mice group. Significance: * p < 0.05; # p < 0.05. DAPI: 4′, 6-diamidino-2-phenylindole. DG: Dentate gyrus.