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. 2019 Nov 12;9(11):728. doi: 10.3390/biom9110728

Figure 6.

Figure 6

Changes in segment-specific HDX kinetics of NQO1 upon FAD and dicoumarol binding. Right panels show fittings of HDX kinetics for selected individual segments using a single exponential function with a burst-phase for NQO1apo (grey), NQO1holo (black) and NQO1dic (red). These data were used to calculate Δ%Dav, as an average of the time points with maximal differences between a given NQO1 form (NQO1holo, black; NQO1dic, red) and NQO1apo, as a single metric to quantify changes in HDX kinetics (left panels).