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Systematic diagram for the development and evaluation of rifampicin PBPK models in healthy and diseased patients. PBPK; Physiologically based pharmacokinetic, ADAM: advanced dissolution, absorption and metabolism, Peff: human jejunum permeability, Vss: volume of distribution at steady-state, CLiv: intravenous clearance, CLR: renal clearance, PK: pharmacokinetic, i.v: intravenous, TB: tuberculosis.
