Fig. 6.

GEFT is upregulated in rhabdomyosarcoma via aberrant promoter hypomethylation. (a) Hierarchical cluster analysis of CpG units’ methylation profiles of the GEFT promoter region in RMS (n = 39) and normal tissues (n = 15). Each vertex indicates one CpG site. Each column represents one sample. The colour gradient between red and blue indicates methylation of each GEFT CpG unit in each sample (0–100%). Grey represents inadequate or missing data. (b) Comparison of average methylation of GEFT promoter between RMS and skeletal muscle tissues. (c) Histogram analysis of the average methylation level of 9 CpG units of the GEFT promoter in RMS and skeletal muscle tissues. (d) Scatter plot of the average methylation level of 9 CpG units of the GEFT promoter in RMS and skeletal muscle tissues. Wilcoxon nonparametric test was used to compare the indexes between two groups.