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. 2019 Oct 11;27(8):1196–1202. doi: 10.1016/j.jsps.2019.10.002

Fig. 4.

Fig. 4

The effect of 5 weeks daily treatment with atorvastatin (50 mg/kg) and rutin (100 mg/kg) on the duration to find the hidden platform (sec) at the Morris water maze. HTG-HFFD animals treated with atorvastatin or rutin needed a significantly shorter time to find the islet even on the 2nd and 3rd day of testing compared to their outputs on the day 1. At the end of the test (Day 4), atorvastatin-treated animals had a significantly shorter time to find the islet. The rats were divided into three groups: HTG-HFFD – hypetriacylglycerolemic rats fed with high-fat-high-fructose diet (HFFD), HTG-HFFD-A – hypertriacylglycerolemic rats fed with HFFD receiving atorvastatin, HTG-HFFD-R – hypertriacylglycerolemic rats fed with HFFD treated with rutin, n = 10 rats/group. Data are expressed as means ± SEM. **p < 0.01 vs 1st day in the given group, #p < 0.05 vs HTG-HFFD untreated group at 4th day.