Fig. 3.

Pre- and post-test probability of HPV16 methylation testing for detection of (a) ≥CIN2 and (b) ≥CIN3 in HPV 16 positive women of a screening population. Colours represent clinical recommendations for degree of risk requiring referral to colposcopy where red = high risk, yellow = moderate risk and green = low risk. Pre-test probability of CIN2⁺ or CIN3⁺ estimated from a HPV16⁺ screening population PPV of CIN2⁺ or CIN3⁺.