Table 3. Factors affecting persistence to treatment for ≥ 24 months (logistic regression analysis).

Variable	90 days definition		60 days definition		30 days definition
	Odds ratio	p-value	Odds ratio	p-value	Odds ratio	p-value
DUT-TAM FDC vs. AB/5ARI free-combination therapy	1.02	0.200	1.22	< 0.001	1.39	< 0.001
Prescriber specialty at index date: Urology	1.25	< 0.001	1.16	< 0.001	1.16	< 0.001
Prescriber specialty at index date: Others	1.04	0.455	1.03	0.572	1.05	0.485
Prescriber specialty at index date: GP	Reference		Reference		Reference
Age ≤ 60	Reference		Reference		Reference
Age 61 – 70	1.68	< 0.001	1.62	< 0.001	1.51	< 0.001
Age 71 – 80	2.08	< 0.001	2.00	< 0.001	1.83	< 0.001
Age > 80	2.00	< 0.001	1.91	< 0.001	1.76	< 0.001
Index year 2011	Reference		Reference		Reference
Index year 2012	1.36	< 0.001	1.33	< 0.001	1.40	< 0.001
Index year 2013	1.41	< 0.001	1.38	< 0.001	1.50	< 0.001
Index year 2014	1.32	< 0.001	1.26	< 0.001	1.25	< 0.001
Index year 2015	1.46	< 0.001	1.36	< 0.001	1.37	< 0.001
Prior treatment with 5ARI	1.14	< 0.001	1.17	< 0.001	1.16	< 0.001
Duration of prior AB treatment: naïve	Reference		Reference		Reference
Duration of prior AB treatment: ≤ 12 months	1.17	< 0.001	1.13	< 0.001	1.09	0.013
Duration of prior AB treatment: 12 – 24 months	1.46	< 0.001	1.34	< 0.001	1.27	< 0.001
Duration of prior AB treatment: > 24 months	1.65	< 0.001	1.60	< 0.001	1.51	< 0.001
Maximal number of ATC classes: 0	0.72	< 0.001	0.72	< 0.001	0.83	0.121
Maximal number of ATC classes: 1 – 3	1.05	0.327	1.10	0.081	1.14	0.064
Maximal number of ATC classes: 4 – 5	1.20	< 0.001	1.25	< 0.001	1.28	< 0.001
Maximal number of ATC classes: 6 – 8	1.18	< 0.001	1.17	0.004	1.15	0.057
Maximal number of ATC classes: > 8	Reference		Reference		Reference

5ARI = 5-α reductase inhibitor; AB = α-blocker; ATC = anatomical therapeutic chemical; DUT-TAM = dutasteride-tamsulosin; FDC = fixed-dose combination; GP = general practitioner.