Fig. 9.

PICSAR regulated cell proliferation, migration and invasion by suppressing miR-4701-5p in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLSs). (a) Overexpression of miR-4701-5p further suppressed the proliferation of RA-FLSs after PICSAR knockdown. (b and c) Evaluated by the quantification of transmembrane cells in Transwell assay and Matrigel Transwell assay respectively, suppressed migratory and invasive capacities of the PICSAR-depleted RA-FLSs were depressed further with miR-4701-5p up-regulation. All the results were presented as the mean ± standard deviation (S.D.) based on ≥ 3 replicates involving ≥3 samples. *P < 0.05, **P < 0.01, and ***P < 0.001 versus control groups.