Table 1.

Histopathologic morphological grading of hypothalamus in perimenopausal depression model mice.

Group	N	−	+	++	+++
BG	10	10	0	0	0
MG	10	0	0	1	9
WG	10	6	7	3	0
EAG	10	0	3	3	4

Note: “−” the hypothalamic nerve cells are large, the patina is rich, and the multi-level synapses are clear; “+” the hypothalamic nerve cells are large, the patina is reduced, and the multi-level synapses are reduced; “++” the hypothalamic nerve cells are reduced, the patina is pyknosis, and the multi-level synapses are reduced; “+++” the hypothalamic nerve cells are significantly reduced, the patina is pyknosis, the synapses are reduced, and the glial cells are pyknosis.