Allergen-specific IgG, IgG1, IgG4 levels during the two treatment years. (A) Phl p 1-, (B) Phl p 2-, (C) Phl p 5- and (D) Phl p 6-specific IgG (left graphs), IgG1 and IgG4 (right graphs) levels were measured by ELISA (Optical density levels OD405nm, y-axes) at indicated time points (x-axes). Lines (Placebo: red circles, BM32: blue squares) represent means with standard deviation shown. Symbols for IgG subclasses are indicated in the legends.