Table 1.
Clinicopathological characteristics of HNSCC patients from two cohorts. A total of 75 HNSCC patients were recruited in this study between July 1, 2016 and July 1, 2017 at the Shandong Provincial Hospital Affiliated to Shandong University, while the TCGA samples were retrieved from the TCGA database.
| Characteristics | Validation patients (N = 75) |
TCGA patients (N = 486) |
||
|---|---|---|---|---|
| N | % | N | % | |
| Age(years) | ||||
| <60 | 32 | 42.7 | 215 | 44.3 |
| ≥60 | 43 | 57.3 | 270 | 55.7 |
| [Not Available] | 0 | 0.0 | 1 | 0.2 |
| Gender | ||||
| Male | 47 | 62.7 | 354 | 72.8 |
| Female | 28 | 37.3 | 132 | 27.2 |
| Lesion site | ||||
| Alveolar Ridge | 3 | 4.0 | 17 | 3.5 |
| Base of tongue | 8 | 10.7 | 24 | 4.9 |
| Buccal Mucosa | 13 | 17.3 | 19 | 3.9 |
| Floor of mouth | 4 | 5.3 | 58 | 11.9 |
| Hard Palate | 5 | 6.7 | 6 | 1.2 |
| Hypopharynx | 3 | 4.0 | 9 | 1.9 |
| Larynx | 5 | 6.7 | 106 | 21.8 |
| Lip | 10 | 13.3 | 3 | 0.6 |
| Oral Cavity | 3 | 4.0 | 70 | 14.4 |
| Oral Tongue | 13 | 17.3 | 125 | 25.7 |
| Oropharynx | 5 | 6.7 | 9 | 1.9 |
| Tonsil | 3 | 4.0 | 40 | 8.2 |
| HPV infection | ||||
| [Not Available] | 75 | 100 | 261 | 53.7 |
| [Not Evaluated] | 0 | 0.0 | 114 | 23.5 |
| [Unknown] | 0 | 0.0 | 8 | 1.6 |
| Positive | 0 | 0.0 | 64 | 13.2 |
| Negative | 0 | 0.0 | 39 | 8.0 |
| TNM staging | ||||
| [Discrepancy] | 0 | 0.0 | 4 | 0.8 |
| [Not Available | 0 | 0.0 | 65 | 13.4 |
| I | 22 | 29.3 | 26 | 5.3 |
| II | 41 | 54.7 | 71 | 14.6 |
| III | 9 | 12.0 | 76 | 15.6 |
| IV | 3 | 4.0 | 244 | 50.2 |
| Histological grade | ||||
| Good | 19 | 25.3 | [Not Available]: 4 | 0.8 |
| G1: 60 | 12.8 | |||
| Moderate | 47 | 62.7 | G2: 282 | 58.0 |
| G3: 117 | 24.1 | |||
| Poor | 9 | 12.0 | G4: 7 | 1.4 |
| GX: 16 | 3.3 | |||
| Tumor recurrence | ||||
| [Not Available] | 0 | 0.0 | 276 | 56.8 |
| [Unknown] | 0 | 0.0 | 14 | 2.9 |
| Yes | 19 | 25.3 | 49 | 10.1 |
| No | 56 | 74.7 | 147 | 30.2 |
| Death | ||||
| Yes | 28 | 37.3 | 155 | 31.9 |
| No | 47 | 62.7 | 331 | 68.1 |
| Smoke | ||||
| Yes | 20 | 26.7 | 357 | 73.5 |
| No | 55 | 73.3 | 116 | 23.9 |
| [Not Available] | 0 | 0.0 | 10 | 2.1 |
| [Unknown] | 0 | 0.0 | 3 | 0.6 |
| Alcohol | ||||
| Yes | 18 | 24.0 | 322 | 66.3 |
| No | 57 | 76.0 | 156 | 32.1 |
| [Not Available] | 0 | 0.0 | 8 | 1.6 |