Table 2.

Diagnostic power of the single and three-miRNA signatures in validation patients. A receiver operating characteristic (ROC) curve analysis was performed, and the area under the ROC curve (AUC) was calculated to evaluate the diagnostic value. The optimal cut-off value, sensitivity, and specificity were determined by calculating the Youden index.

miRNAs	Optimal cut-off value	Se (%)	Sp (%)	AUC	95% CI	P
mir-383	1.175	93.3	88.0	0.924	0.880–0.967	<0.0001
mir-615	0.855	82.6	97.3	0.890	0.837–0.942	<0.0001
mir-877	0.715	81.5	89.3	0.868	0.810–0.926	<0.0001
mir-383/mir-615/mir-877	0.129	89.3	98.9	0.986	0.973–0.999	<0.0001

Se, Sensitivity; Sp, Specificity; AUC, Area Under the Curve; CI, Confidence Interval.