Additional Table 1
| Category | Term | Count | % | P-value | Molecules | List total | Pop hits | Pop total | Fold enrichmen | Bonferroni | Benjamini | FDR |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Day 1 | ||||||||||||
| KEGG_PATHWA Y | ssc04060:Cytokine- cytokine receptor interaction | 13 | 0.33121019 | 3.40E-13 | VEGFB, IL4, CCL2, PPBP, IL6ST, TNFRSF12A, CXCL13, VEGFA, CXCL9, NGFR, CXCL11, IL10, | 23 | 221 | 7030 | 17.97953964 | 2.04E-11 | 2.04E-11 | 3.40E-10 |
| KEGG_PATHWA Y | ssc04062:Chemokine signaling pathway | 9 | 0.22929936 | 2.73E-08 | CCL2,PPBP, CXCL13, CXCL2, CXCL9, JAK2, CXCL11, CCL17, CXCL10 | 23 | 173 | 7030 | 15.90098015 | 1.64E-06 | 8.18E-07 | 2.73E-05 |
| KEGG_PATHWA Y | ssc04630:Jak-STAT signaling pathway | 6 | 0.15286624 | 5.85E-05 | IL4, IL6ST, IL19, JAK2, IL10, IL20 | 23 | 140 | 7030 | 13.09937888 | 0.003500988 | 0.00116836 | 0.05856165 |
| KEGG_PATHWA Y | ssc04151:PI3K-Akt signaling pathway | 6 | 0.15286624 | 0.00285045 | IL4, VEGFB, PGF, VEGFA, JAK2, NGFR | 23 | 326 | 7030 | 5.625500133 | 0.157406886 | 0.04191404 | 2.820171 |
| KEGG_PATHWA Y | ssc04668:TNF signaling pathway | 4 | 0.10191083 | 0.00439045 | ICAM1, CCL2, CXCL2, CXCL10 | 23 | 108 | 7030 | 11.32045089 | 0.232031866 | 0.05143163 | 4.31383707 |
| KEGG_PATHWA | ssc05144:Malaria | 3 | 0.07643312 | 0.01127811 | ICAM1, CCL2, IL10 | 23 | 52 | 7030 | 17.63377926 | 0.493652212 | 0.1072261 | 10.7445415 |
| KEGG_PATHWA | ssc05164:Influenza A | 4 | 0.10191083 | 0.0145511 | ICAM1, CCL2, JAK2, CXCL10 | 23 | 167 | 7030 | 7.321010154 | 0.585001467 | 0.11806775 | 13.6617584 |
| KEGG_PATHWA | ssc05140:Leishmanias | 3 | 0.07643312 | 0.01578332 | IL4, JAK2, IL10 | 23 | 62 | 7030 | 14.78962132 | 0.615015566 | 0.11247541 | 14.7376045 |
| KEGG_PATHWA Y | ssc04015:Rap1 signaling pathway | 4 | 0.10191083 | 0.02533146 | VEGFB, PGF, VEGFA, NGFR | 23 | 206 | 7030 | 5.934993668 | 0.785505085 | 0.15722237 | 22.6735405 |
| KEGG_PATHWA Y | ssc05323:Rheumatoid arthritis | 3 | 0.07643312 | 0.02916058 | ICAM1, CCL2, VEGFA | 23 | 86 | 7030 | 10.66228514 | 0.830627048 | 0.16269361 | 25.6646135 |
| KEGG_PATHWA Y | ssc04014:Ras signaling pathway | 4 | 0.10191083 | 0.03002464 | VEGFB, PGF, VEGFA, NGFR | 23 | 220 | 7030 | 5.557312253 | 0.8394382 | 0.15319063 | 26.3249811 |
| KEGG_PATHWA Y | ssc04620:Toll-like receptor signaling pathway | 3 | 0.07643312 | 0.03917298 | CXCL9, CXCL11, CXCL10 | 23 | 101 | 7030 | 9.078777443 | 0.909068921 | 0.18110913 | 32.9997956 |
| KEGG_PATHWA | ssc05310:Asthma | 2 | 0.05095541 | 0.06965828 | IL4, IL10 | 23 | 23 | 7030 | 26.57844991 | 0.986861379 | 0.28340618 | 51.4995559 |
| Day 7 | ||||||||||||
| KEGG_PATHWA Y | ssc04060:Cytokine- cytokine receptor interaction | 14 | 0.20548951 | 2.8045E-13 | IL4, CCL2, IL7, TNFRSF12A, IL6ST, IL9, CCL5, CCL27, IL10, VEGFB, CNTF, PPBP, VEGFA, IFNG | 28 | 221 | 7030 | 15.90497738 | 2.04723E-11 | 2.0472E-11 | 2.9272E-10 |
| KEGG_PATHWA Y | ssc04630:Jak-STAT signaling pathway | 10 | 0.14677822 | 1.3162E-09 | IL4, CNTF, IL6ST, IL7, IFNG, IL19, IL9, JAK2, IL10, IL20 | 28 | 140 | 7030 | 17.93367347 | 9.60815E-08 | 4.8041E-08 | 1.3738E-06 |
| KEGG_PATHWA Y | ssc05323:Rheumatoid arthritis | 5 | 0.07338911 | 0.00029559 | ICAM1, CCL2, IFNG, VEGFA, CCL5 | 28 | 86 | 7030 | 14.59717608 | 0.021350158 | 0.00716798 | 0.30810644 |
| KEGG_PATHWA | ssc05144:Malaria | 4 | 0.05871129 | 0.00098511 | ICAM1, CCL2, IFNG, IL10 | 28 | 52 | 7030 | 19.31318681 | 0.06942148 | 0.0178264 | 1.02348937 |
| KEGG_PATHWA | ssc05140:Leishmanias | 4 | 0.05871129 | 0.00164329 | IL4, IFNG, JAK2, IL10 | 28 | 62 | 7030 | 16.19815668 | 0.113131722 | 0.02372577 | 1.70201483 |
| KEGG_PATHWA | ssc05310:Asthma | 3 | 0.04403347 | 0.00341977 | IL4, IL9, IL10 | 28 | 23 | 7030 | 32.7484472 | 0.221254387 | 0.04082187 | 3.51247659 |
| KEGG_PATHWA | ssc05164:Influenza A | 5 | 0.07338911 | 0.00351799 | ICAM1, CCL2, IFNG, JAK2, CCL5 | 28 | 167 | 7030 | 7.51710864 | 0.226837364 | 0.0360851 | 3.61169015 |
| KEGG_PATHWA Y | ssc04062:Chemokine signaling pathway | 5 | 0.07338911 | 0.00399326 | CCL2, PPBP, JAK2, CCL5, CCL27 | 28 | 173 | 7030 | 7.25639967 | 0.253300018 | 0.03585297 | 4.0904725 |
| KEGG_PATHWA Y | ssc04151:PI3K-Akt signaling pathway | 6 | 0.08806693 | 0.00722646 | IL4, VEGFB, PGF, IL7, VEGFA, JAK2 | 28 | 326 | 7030 | 4.620946538 | 0.411069421 | 0.05713054 | 7.29086559 |
| KEGG_PATHWA Y | ssc05143:African trypanosomiasis | 3 | 0.04403347 | 0.00738845 | ICAM1, IFNG, IL10 | 28 | 34 | 7030 | 22.15336134 | 0.418043509 | 0.0526967 | 7.44864556 |
| KEGG_PATHWA Y | ssc05142:Chagas disease (American trypanosomiasis) | 4 | 0.05871129 | 0.00768878 | CCL2, IFNG, CCL5, ILIO | 28 | 107 | 7030 | 9.385847797 | 0.430758015 | 0.04993293 | 7.74051304 |
| KEGG_PATHWA Y | sscO5330:Allograft rejection | 3 | 0.04403347 | 0.00870947 | IL4, IFNG, IL10 | 28 | 37 | 7030 | 20.35714286 | 0.471956101 | 0.05182354 | 8.72625592 |
| KEGG_PATHWA Y | SSC04330:Notch signaling pathway | 3 | 0.04403347 | 0.0121687 | NOTCH2, JAG2, JAG1 | 28 | 44 | 7030 | 17.11850649 | 0.590887078 | 0.06644097 | 11.9966412 |
| KEGG_PATHWA Y | ssc05321:Inflammator y bowel disease (IBD) | 3 | 0.04403347 | 0.02261767 | IL4, IFNG, IL10 | 28 | 61 | 7030 | 12.34777518 | 0.811761955 | 0.11244886 | 21.2421676 |
| KEGG_PATHWA Y | ssc05168:Herpes simplex infection | 4 | 0.05871129 | 0.03164347 | CCL2, IFNG, JAK2, CCL5 | 28 | 182 | 7030 | 5.518053375 | 0.904374051 | 0.14485771 | 28.5113284 |
| KEGG_PATHWA Y | ssc04066:HIF-1 signaling pathway | 3 | 0.04403347 | 0.05684533 | IFNG, VEGFA, TIMP1 | 28 | 101 | 7030 | 7.457567185 | 0.986050678 | 0.23434245 | 45.7127052 |
| KEGG_PATHWA Y | ssc04660:T cell receptor signaling pathway | 3 | 0.04403347 | 0.06191833 | IL4, IFNG, IL10 | 28 | 106 | 7030 | 7.105795148 | 0.990590483 | 0.24002715 | 48.684362 |
| KEGG_PATHWA Y | ssc04668:TNF signaling pathway | 3 | 0.04403347 | 0.0639902 | ICAM1, CCL2, CCL5 | 28 | 108 | 7030 | 6.974206349 | 0.991993018 | 0.23523844 | 49.8551108 |
| KEGG_PATHWAY | ssc05145:Toxoplasmo sis | 3 | 0.04403347 | 0.07034613 | IFNG, JAK2, IL10 | 28 | 114 | 7030 | 6.607142857 | 0.995130845 | 0.24440856 | 53.2975516 |
| KEGG_PATHWA | ssc05162:Measles | 3 | 0.04403347 | 0.09057419 | IL4, IFNG, JAK2 | 28 | 132 | 7030 | 5.706168831 | 0.999022737 | 0.29286788 | 62.8793488 |
| Day 14 | ||||||||||||
| KEGG_PATHWA Y | rno04062:Chemokine signaling pathway | 7 | 0.16252612 | 1.88E-06 | CXCL1, CCL1, CCL12, CCL2, CXCL2, CCL5, CCL7 | 19 | 177 | 7780 | 16.19387452 | 7.92E-05 | 7.92E-05 | 1.74E-03 |
| KEGG_PATHWA Y | rno04668:TNF signaling pathway | 6 | 0.1393081 | 3.65E-06 | CXCL1, ICAM1, CCL12, CCL2, CXCL2, CCL5 | 19 | 109 | 7780 | 22.53983583 | 1.53E-04 | 7.66E-05 | 3.38E-03 |
| KEGG_PATHWA Y | rno04060: Cytokine- cytokine receptor interaction | 7 | 0.16252612 | 6.00E-06 | CCL12, CCL2, CNTF, VEGFA, CCL5, IL22, CCL7 | 19 | 216 | 7780 | 13.26998051 | 2.52E-04 | 8.40E-05 | 5.55E-03 |
| KEGG_PATHWA Y | rno05323:Rheumatoid arthritis | 5 | 0.11609009 | 4.53E-05 | ICAM1, CCL12, CCL2, VEGFA, CCL5 | 19 | 90 | 7780 | 22.74853801 | 1.90E-03 | 4.75E-04 | 4.19E-02 |
| KEGG_PATHWA Y | rno05206:MicroRNAs | 5 | 0.11609009 | 2.74E-04 | NOTCH3, NOTCH2, NOTCH1, VEGFA, | 19 | 143 | 7780 | 14.31726169 | 1.14E-02 | 2.30E-03 | 2.53E-01 |
| in cancer | TIMP3 | |||||||||||
| KEGG_PATHWA Y | rno04320:Dorso- ventral axis formation | 3 | 0.06965405 | 1.47E-03 | NOTCH3, NOTCH2, NOTCH1 | 19 | 25 | 7780 | 49.13684211 | 5.99E-02 | 1.02E-02 | 1.35E+00 |
| KEGG_PATHWA Y | rno04330:Notch | 3 | 0.06965405 | 6.26E-03 | NOTCH3, NOTCH2, NOTCH1 | 19 | 52 | 7780 | 23.62348178 | 2.32E-01 | 3.70E-02 | 5.65E+00 |
| signaling pathway | ||||||||||||
| KEGG_PATHWA | rno05164:Influenza A | 4 | 0.09287207 | 6.68E-03 | ICAM1, CCL12, CCL2, CCL5 | 19 | 171 | 7780 | 9.578331794 | 2.45E-01 | 3.46E-02 | 6.01E+00 |
| KEGG_PATHWA Y | rno04621:NOD-like receptor signaling pathway | 3 | 0.06965405 | 7.23E-03 | CCL12, CCL2, CCL5 | 19 | 56 | 7780 | 21.93609023 | 2.63E-01 | 3.33E-02 | 6.50E+00 |
| KEGG_PATHWA | rno05144:Malaria | 3 | 0.06965405 | 8.00E-03 | ICAM1, CCL12, CCL2 | 19 | 59 | 7780 | 20.82069581 | 2.86E-01 | 3.32E-02 | 7.17E+00 |
| KEGG_PATHWA Y | rno05142:Chagas disease (American trypanosomiasis) | 3 | 0.06965405 | 2.48E-02 | CCL12, CCL2, CCL5 | 19 | 107 | 7780 | 11.48057059 | 6.52E-01 | 9.16E-02 | 2.08E+01 |
| KEGG_PATHWA Y | rno04919:Thyroid hormone signaling pathway | 3 | 0.06965405 | 2.84E-02 | NOTCH3, NOTCH2, NOTCH1 | 19 | 115 | 7780 | 10.6819222 | 7.02E-01 | 9.59E-02 | 2.34E+01 |
| KEGG_PATHWA Y | rno04514:Cell adhesion molecules | 3 | 0.06965405 | 5.90E-02 | ICAM1, F11R, ICAM2 | 19 | 172 | 7780 | 7.141982864 | 9.22E-01 | 1.78E-01 | 4.30E+01 |
| KEGG_PATHWA Y | rno05168:Herpes simplex infection | 3 | 0.06965405 | 8.78E-02 | CCL12, CCL2, CCL5 | 19 | 216 | 7780 | 5.687134503 | 9.79E-01 | 2.41E-01 | 5.73E+01 |
| Day 28 | ||||||||||||
| KEGG_PATHWA Y | cfa04330:Notch signaling pathway | 5 | 0.10957703 | 3.4697E-06 | NOTCH3, NOTCH2, NOTCH1, JAG2, | 17 | 47 | 6781 | 42.43429287 | 2.64E-04 | 0.00026366 | 3.65E-03 |
| JAG1 | ||||||||||||
| KEGG_PATHWA Y | cfa05206:MicroRNAs in cancer | 6 | 0.13149244 | 1.2266E-05 | NOTCH3, NOTCH2, NOTCH1, HRAS, | 17 | 139 | 6781 | 17.21794329 | 9.32E-04 | 0.000466 | 1.29E-02 |
| VEGFA, TIMP3 | ||||||||||||
| KEGG_PATHWA Y | cfa04320:Dorso- ventral axis formation | 3 | 0.06574622 | 0.0017703 | NOTCH3, NOTCH2, NOTCH1 | 17 | 27 | 6781 | 44.32026144 | 1.26E-01 | 0.04389487 | 1.85E+00 |
| KEGG_PATHWA Y | cfa04919:Thyroid hormone signaling pathway | 4 | 0.08766163 | 0.00215415 | NOTCH3, NOTCH2, NOTCH1, HRAS | 17 | 113 | 6781 | 14.11972931 | 1.51E-01 | 0.04014488 | 2.24E+00 |
| KEGG_PATHWA Y | cfa04510:Focal adhesion | 4 | 0.08766163 | 0.01170373 | VEGFB, HRAS, PGF, VEGFA | 17 | 207 | 6781 | 7.707871554 | 5.91E-01 | 0.16384884 | 1.17E+01 |
| KEGG_PATHWA Y | cfa04015:Rap1 signaling pathway | 4 | 0.08766163 | 0.01170373 | VEGFB, HRAS, PGF, VEGFA | 17 | 207 | 6781 | 7.707871554 | 5.91E-01 | 0.16384884 | 1.17E+01 |
| KEGG_PATHWA Y | cfa04060: Cytokine- cytokine receptor interaction | 4 | 0.08766163 | 0.01313391 | VEGFB, CNTF, VEGFA, CCL5 | 17 | 216 | 6781 | 7.38671024 | 6.34E-01 | 0.15419378 | 1.30E+01 |
| KEGG_PATHWA Y | cfa04014:Ras signaling pathway | 4 | 0.08766163 | 0.01346491 | VEGFB, HRAS, PGF, VEGFA | 17 | 218 | 6781 | 7.318942256 | 6.43E-01 | 0.13686453 | 1.33E+01 |
| KEGG_PATHWA Y | cfa05323:Rheumatoid arthritis | 3 | 0.06574622 | 0.01553142 | ICAM1, VEGFA, CCL5 | 17 | 82 | 6781 | 14.59325681 | 6.96E-01 | 0.13817783 | 1.52E+01 |
| KEGG_PATHWA Y | cfa04650:Natural killer cell mediated cytotoxicity | 3 | 0.06574622 | 0.02174666 | ICAM1, HRAS, ICAM2 | 17 | 98 | 6781 | 12.21068427 | 8.12E-01 | 0.16944791 | 2.07E+01 |
| KEGG_PATHWA Y | cfa04151:PI3K-Akt signaling pathway | 4 | 0.08766163 | 0.0420905 | VEGFB, HRAS, PGF, VEGFA | 17 | 337 | 6781 | 4.73450864 | 9.62E-01 | 0.27878282 | 3.64E+01 |
| KEGG_PATHWA Y | cfa05200:Pathways in cancer | 4 | 0.08766163 | 0.06126129 | VEGFB, HRAS, PGF, VEGFA | 17 | 392 | 6781 | 4.070228091 | 9.92E-01 | 0.35388619 | 4.86E+01 |
| KEGG_PATHWA Y | cfa05205:Proteoglyca ns in cancer | 3 | 0.06574622 | 0.07581922 | HRAS, VEGFA, TIMP3 | 17 | 195 | 6781 | 6.136651584 | 9.98E-01 | 0.39308589 | 5.64E+01 |
| KEGG_PATHWA Y | cfa05219:Bladder cancer | 2 | 0.04383081 | 0.09257318 | HRAS, VEGFA | 17 | 41 | 6781 | 19.45767575 | 9.99E-01 | 0.4332909 | 6.40E+01 |