Additional Table 3
| Category | Term | Count | % | P-value | Molecules | List | total Pop hits | Pop total | Fold enrichmei | Bonferroni | Benjamini | FDR |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Day 1 | ||||||||||||
| GOTERM_CC_DIRECT | GO:0005615~extracellula r space | 20 | 0.50955414 | 5.00E-19 | IL4, ICAM1, NRP1, CCL2, LGALS3, PGF, LGALS1, CXCL2, IL19, CXCL9, CXCL11, IL10, IL20, CCL17, TIMP1, CXCL10, VEGFB, PPBP, CXCL13, VEGFA | 26 | 762 | 12833 | 12.95477488 | 1.85E-17 | 1.85E-17 | 4.49E-16 |
| GOTERM_CC_DIRECT | GO:0009897~external side of plasma membrane | 5 | 0.12738854 | 7.90E-05 | IL4, ICAM1, IL6ST, CXCL9, CXCL10 | 26 | 120 | 12833 | 20.56570513 | 0.00291951 | 0.00146082 | 0.07092918 |
| GOTERM_CC_DIRECT | GO:0001772~immunologi cal synapse | 2 | 0.05095541 | 0.04576193 | ICAM1, LGALS3 | 26 | 24 | 12833 | 41.13141026 | 0.82327447 | 0.43882313 | 34.3348902 |
| GOTERM_CC_DIRECT | GO:0016020~membrane | 5 | 0.12738854 | 0.04595763 | VEGFB, PGF, ICAM2, VEGFA, | 26 | 707 | 12833 | 3.49064302 | 0.8246105 | 0.35285604 | 34.4557081 |
| Day 7 | ||||||||||||
| GOTERM_CC_DIRECT | GO:0005615~extracellula r space | 23 | 0.3375899 | 1.4551E-17 | IL4, ICAM1, CCL2, NRP1, LGALS3, PGF, IL7, LGALS1, IL9, IL1RN, IL19, TIMP4, TIMP2, CCL5, TIMP3, IL10, IL20, TIMP1, VEGFB, CNTF, PPBP, IFNG, VEGFA | 40 | 762 | 12833 | 9.683694226 | 6.1114E-16 | 6.1114E-16 | 1.3467E-14 |
| GOTERM_CC_DIRECT | GO:0009897~external side of plasma membrane | 5 | 0.07338911 | 0.00046445 | IL4, ICAM1, IL6ST, IFNG, GFRA3 | 40 | 120 | 12833 | 13.36770833 | 0.01932219 | 0.00970822 | 0.42902184 |
| GOTERM_CC_DIRECT | GO:0005578~proteinaceo us extracellular matrix | 5 | 0.07338911 | 0.00087497 | LGALS1, TIMP4, TIMP2, TIMP3, TIMP1 | 40 | 142 | 12833 | 11.29665493 | 0.03609734 | 0.0121802 | 0.80686791 |
| GOTERM_CC_DIRECT | GO:0005576~extracellula r region | 7 | 0.10274475 | 0.00131741 | NRTN, IL7, ADIPOQ, GDNF, FGFBP1, CCL27, TIMP1 | 40 | 407 | 12833 | 5.517874693 | 0.053863 | 0.01374662 | 1.21265635 |
| GOTERM_CC_DIRECT | GO:0005622~intracellular | 6 | 0.08806693 | 0.03118422 | VEGFB, CCL2, GFRAL, LGALS1, IFNG, GFRA2 | 40 | 586 | 12833 | 3.284897611 | 0.73567964 | 0.23365183 | 25.4130934 |
| GOTERM_CC_DIRECT | GO:0001772~immunologi cal synapse | 2 | 0.02935564 | 0.07050482 | ICAM1, LGALS3 | 40 | 24 | 12833 | 26.73541667 | 0.95361474 | 0.40058169 | 49.1690919 |
| GOTERM_CC_DIRECT | GO:0005604~basement membrane | 2 | 0.02935564 | 0.08457142 | TIMP3, TIMP1 | 40 | 29 | 12833 | 22.12586207 | 0.97555289 | 0.41149956 | 55.8597181 |
| Day 14 | ||||||||||||
| GOTERM_CC_DIRECT | GO:0005615~extracellula r space | 21 | 0.48757836 | 2.2092E-15 | CXCL1, CCL1, ICAM1, HAVCR1, CCL2, ICAM4, LGALS3, LGALS1, CXCL2, TIMP4, CCL5, TIMP2, TIMP3, IL22, CCL7, TIMP1, CCL12, CNTF, VEGFA, GFRA1, GFRA4 | 34 | 1316 | 18520 | 8.692115144 | 1.5099E-13 | 1.5099E-13 | 2.2871E-12 |
| GOTERM_CC_DIRECT | GO:0005578~proteinaceo us extracellular matrix | 6 | 0.1393081 | 7.9388E-05 | LGALS3, LGALS1, TIMP4, TIMP2, TIMP3, TIMP1 | 34 | 253 | 18520 | 12.91792606 | 0.00538405 | 0.00269566 | 0.08164213 |
| GOTERM_CC_DIRECT | GO:0009986~cell surface | 8 | 0.18574414 | 8.3982E-05 | ICAM1, NOTCH2, NOTCH1, HAVCR1, LGALS3, LGALS1, VEGFA, TIMP2 | 34 | 612 | 18520 | 7.120338331 | 0.00569472 | 0.00190185 | 0.0863644 |
| GOTERM_CC_DIRECT | GO:0005604~basement membrane | 4 | 0.09287207 | 0.00059964 | VEGFA, TIMP2, TIMP3, TIMP1 | 34 | 93 | 18520 | 23.42820999 | 0.03996739 | 0.01014519 | 0.6151823 |
| GOTERM_CC_DIRECT | GO:0043235~receptor complex | 4 | 0.09287207 | 0.00165145 | NOTCH3, NOTCH2, NOTCH1, GFRA1 | 34 | 132 | 18520 | 16.50623886 | 0.10630582 | 0.02222757 | 1.68599929 |
| GOTERM_CC_DIRECT | G0:0031012~extracellula r matrix | 4 | 0.09287207 | 0.01026878 | LGALS3, LGALS1, TIMP3, TIMP1 | 34 | 254 | 18520 | 8.578045391 | 0.50435096 | 0.11039808 | 10.0744937 |
| GOTERM_CC_DIRECT | GO:0009897~external side of plasma membrane | 4 | 0.09287207 | 0.01174935 | ICAM1, LGALS3, GFRA1, GFRA3 | 34 | 267 | 18520 | 8.160387751 | 0.55232434 | 0.10846655 | 11.4488433 |
| GOTERM_CC_DIRECT | GO:0005886~plasma membrane | 14 | 0.32505224 | 0.01438302 | F11R, ICAM1, LGALS3, ICAM4, GFRAL, ICAM5, ICAM2, GAS1, NOTCH3, NOTCH2, NOTCH1, GFRA1, GFRA4, GFRA3 | 34 | 3963 | 18520 | 1.924270087 | 0.62661575 | 0.11586313 | 13.8467933 |
| GOTERM_CC_DIRECT | GO:0005623~cell | 3 | 0.06965405 | 0.01898445 | CXCL1, CCL12, CXCL2 | 34 | 119 | 18520 | 13.73208107 | 0.72838062 | 0.13481944 | 17.8960826 |
| GOTERM_CC_DIRECT | GO:0005887~integral component of plasma membrane | 6 | 0.1393081 | 0.02446583 | ICAM1, NOTCH2, ICAM4, ICAM5, ICAM2, TCAM1 | 34 | 942 | 18520 | 3.469464219 | 0.81443802 | 0.1550152 | 22.495014 |
| GOTERM_CC_DIRECT | GO:0070062~extracellula r exosome | 10 | 0.23218017 | 0.03763242 | ICAM1, F11R, LGALS3, ICAM2, LGALS1, GFRA1, GFRA4, TIMP2, TIMP3, TIMP1 | 34 | 2646 | 18520 | 2.058601218 | 0.92634761 | 0.21110903 | 32.6067177 |
| GOTERM_CC_DIRECT | GO:0001772~immunologi cal synapse | 2 | 0.04643603 | 0.05888631 | ICAM1, LGALS3 | 34 | 34 | 18520 | 32.04152249 | 0.98386897 | 0.29101261 | 46.440432 |
| GOTERM_CC_DIRECT | GO:0043025~neuronal cell body | 4 | 0.09287207 | 0.07056971 | CCL2, CNTF, GFRA1, TIMP2 | 34 | 540 | 18520 | 4.034858388 | 0.99310167 | 0.31805473 | 52.8997324 |
| GOTERM_CC_DIRECT | GO:0031225~anchored component of membrane | 2 | 0.04643603 | 0.09356231 | GFRA1, GFRA4 | 34 | 55 | 18520 | 19.80748663 | 0.99874403 | 0.37943918 | 63.5997306 |
| Day 28 | ||||||||||||
| GOTERM_CC_DIRECT | GO:0005615~extracellula r space | 12 | 0.26298488 | 2.1928E-07 | VEGFB, ICAM1, NRP1, CNTF, ICAM4, LGALS3, VEGFA, TIMP4, TIMP2, CCL5, TIMP3, TIMP1 | 29 | 814 | 13919 | 7.075658731 | 8.5518E-06 | 8.5518E-06 | 0.00019941 |
| GOTERM_CC_DIRECT | GO:0005578~proteinaceo us extracellular matrix | 4 | 0.08766163 | 0.00409476 | TIMP4, TIMP2, TIMP3, TIMP1 | 29 | 162 | 13919 | 11.85100043 | 0.14787636 | 0.07689457 | 3.6626419 |
| GOTERM_CC_DIRECT | GO:0043235~receptor complex | 3 | 0.06574622 | 0.01401283 | NOTCH3, NOTCH2, NOTCH1 | 29 | 90 | 13919 | 15.99885057 | 0.42326116 | 0.16761087 | 12.0439761 |
| GOTERM_CC_DIRECT | GO:0005887~integral component of plasma membrane | 6 | 0.13149244 | 0.01431117 | ICAM1, NOTCH2, ICAM4, ICAM5, ICAM2, JAG2 | 29 | 733 | 13919 | 3.928776403 | 0.43002802 | 0.13111284 | 12.2857025 |
| GOTERM_CC_DIRECT | GO:0005912~adherens junction | 2 | 0.04383081 | 0.04336572 | NOTCH1, JAG1 | 29 | 22 | 13919 | 43.63322884 | 0.82254361 | 0.2923503 | 33.1802839 |
| GOTERM_CC_DIRECT | GO:0001772~immunologi cal synapse | 2 | 0.04383081 | 0.05677946 | ICAM1, LGALS3 | 29 | 29 | 13919 | 33.10107015 | 0.89769033 | 0.31611022 | 41.2328984 |
| GOTERM_CC_DIRECT | GO:0005604~basement membrane | 2 | 0.04383081 | 0.08676185 | TIMP3, TIMP1 | 29 | 45 | 13919 | 21.33180077 | 0.97097463 | 0.3968896 | 56.1919967 |