Figure 2.

Scheme showing Glu receptors and glutamate release from Schwann cells located in the peripheral nerves.

Note that several studies report that AMPARs, NMDARs and mGluRs are functional proteins in SCs, but only morphological evidence is available regarding KARs in SCs. Also note that mechanisms of Glu release from SCs are hypothetical as no functional studies are available on this topic. AMPAR: α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; Glu: glutamate; KAR: kainate receptor; mGluR: metabotropic Glu receptor; NMDAR: N-methyl-D-aspartate receptor; SC: Schwann cell.