Table 2.

Risk of bias evaluated by SYRCLE’s RoB tool

Study	Selection bias			Performance bias		Detection bias		Attrition bias	Reporting bias	Other
	Sequence generation	Baseline characteristics	Allocation concealment	Random housing	Blinding	Random outcome assessment	Blinding	Incomplete outcome data	Selective outcome reporting	Free of contamination	Free of inappropriate influence of funders	Free of unit of analysis errors	Design-specific risks of bias	New animals added to replace drop-outs
King et al. (2006)	Unclear	Yes	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Yes	Unclear	Unclear	Yes	Yes	Unclear
Huang et al. (2007)	Unclear	Yes	Unclear	Unclear	Unclear	Unclear	Yes	No	Yes	Unclear	Unclear	Yes	Yes	Unclear
Emon et al. (2011)	Unclear	Yes	Yes	Unclear	Unclear	Unclear	Yes	Yes	Yes	Unclear	Unclear	Yes	Yes	Unclear
Figueroa et al. (2012)	Unclear	Yes	Unclear	Unclear	Unclear	Unclear	Yes	No	Yes	Unclear	Yes	Yes	Yes	Unclear
Figueroa et al. (2013)	Unclear	Yes	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Yes	Unclear	Yes	Yes	Yes	Unclear
Liu et al. (2015)	Unclear	Yes	Unclear	Unclear	Unclear	Unclear	Yes	Unclear	Yes	Unclear	Unclear	Yes	Yes	Unclear
Figueroa et al. (2016)	Unclear	Yes	Unclear	Unclear	Unclear	Unclear	Yes	Unclear	Yes	Unclear	Yes	Yes	Yes	Unclear
Jiang et al. (2016)	Unclear	Yes	Yes	Unclear	Unclear	Unclear	Yes	Yes	Yes	Unclear	Unclear	Yes	Yes	Unclear
Tremoled et al. (2016)	Unclear	Yes	Unclear	Unclear	Unclear	Unclear	Yes	Yes	Yes	Unclear	Yes	Yes	Yes	Unclear
Liu et al. (2017)	Unclear	Yes	Unclear	Unclear	Unclear	Unclear	Yes	Unclear	Yes	Unclear	Unclear	Yes	Yes	Unclear
Yu and Guo (2017)	Unclear	Yes	Yes	Unclear	Unclear	Unclear	Unclear	Unclear	Yes	Unclear	Unclear	Yes	Yes	Unclear
Manzhulo et al. (2018a)	Unclear	Yes	Unclear	Unclear	Unclear	Unclear	Unclear	Yes	Yes	Unclear	Yes	Yes	Yes	Unclear