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. 2019 Nov 19;50:224–237. doi: 10.1016/j.ebiom.2019.11.011

Fig. 3.

Fig. 3

Ethanol itself directly promotes the aggressiveness of CRC cells. (A) Ultraviolet spectrophotometer assay of the activity of ADH in normal hepatic and colorectal cell lines as well as six CRC cell lines. (B) Ultraviolet spectrophotometer assay of the activity of ADH in normal epithelial and CRC cell lines. “4-MP” indicates 4-methylpyrazole. (C) A Transwell assay with Matrigel was used to investigate the invasion ability of CRC cells. The bars in the right panel reflect the means ± SEMs. (D) A Transwell assay without Matrigel was used to investigate the migration ability of CRC cells. The bars in the right panel reflect the means ± SEMs. (E) A wound-healing assay was used to investigate the motility of CRC cells. (E) Representative images from the mouse tail-vein assay. The bars in the right panel reflect the means ± SEMs; *P < 0.05 and n.sP > 0.05 vs the control.