Fig. 6.

Phylogenetic analysis of yadC.

Phylogenetic trees of 47 UPEC strains with available genome sequences based on yadC (a) and MLST (b). Rectangles with different colors indicate different subgroups separated in the tree. (c) A phylogenetic tree of 27 clinical UPEC isolates and the representative strains (CFT073, UTI89, 11, Ec958, 4, and 7, indicated by red circles) of the six separated subgroups in (a). Rectangles with different colors indicate the corresponding subgroups in (a). The scales at the bottoms of the trees indicate the phylogenetic distance. Bootstrap values are displayed as percentages on the nodes (a–c). (d) Schematic diagram of YadC-mediated acute bladder infections and three treatment strategies.