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Comparison of scSplit and demuxlet performance in demultiplexing multiplexed eight individually genotyped PBMC samples (TPR true positive rate, FDR false discovery rate); total cell numbers: 6145; reads per cell: 33,119; informative SNVs: 22,757; runtime for matrices building: 45 min; runtime for cell assignment: 35 min
| scSplit vs demuxlet | TPR | FDR | Cohen’s Kappa |
|---|---|---|---|
| Singlets | 0.80 | 0.18 | 0.63 |
| Doublets | 0.12 | 0.92 |
