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. 2019 Dec 19;20(Suppl 1):81. doi: 10.1186/s40360-019-0358-y

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Plasma concentration versus time of TAM and NDTAM (upper panels) and 4-HTAM and END (lower panels) observed during a dosing interval of TAM therapy (20 mg/day) in all investigated TAM-treated breast cancer patients (n = 40). The value of 6 ng/ml END corresponds to the threshold associated with efficacy