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. 2019 Dec 19;19(Suppl 6):271. doi: 10.1186/s12911-019-0964-z

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — differential expressing analysis and downstream pathway/network analysis. a Tendency of miRNA alteration.x-axis:log2(fold change) in case vs. control; y-axis:log2(fold change) in treat vs. case. Colored dots represent miRNAs that reach criteria of significant differential expression (FDR < 0.05, absolute log2FC > 1). b top GO-BP and KEGG pathways for case vs. control DE-miRNA targets. c top GO-BP and KEGG pathways for treat vs. case DE-miRNA targets. d Network analysis for case vs. control DE-miRNA. d Network analysis for treat vs. case DE-miRNA. For (d, e), triangles represent miRNAs and circles represent transcription products of genes. A straight line means that the mRNA is predicted to be regulated by the miRNA, and the color of the line represents the context score of this prediction (see method). Red lines represent a lower score, which means the prediction is highly credible