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Physicochemical characterization of the formulations
| Particle size (nm) | Zeta potential (mV) | pH | Span | PDI | ||
|---|---|---|---|---|---|---|
| D [3, 4]a | z-averageb | |||||
| LNC | 205 ± 4.4 | 199 ± 0.2 | - 6.40 ± 0.6 | 5.36 ± 0.3 | 1.74 ± 0.02 | 0.10 ± 0.01 |
| Mel-LNC | 203 ± 3.6 | 199 ± 2.5 | −5.20 ± 0.2 | 5.46 ± 0.2 | 1.77 ± 0.02 | 0.12 ± 0.04 |
alaser diffratometry; bdynamic light scattering analysis; LNC Unloaded lipid-core nanocapsules, Mel-LNC Melatonin-loaded lipid-core nanocapsules. Results are expressed as mean ± SD. Number of samples?
