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. 2019 Dec 18;10:401. doi: 10.1186/s13287-019-1516-2

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — The twofold enriched hBM-MSC-sEV proteomics dataset analyzed for biological significance. Twofold enriched hBM-MSC-sEV protein dataset as compared to the parental hBM-MSCs. a Described in a volcano plot showing the significantly enriched proteins (upper right corner) in the overall proteomics dataset. b categorized into protein class, and c categorized into subcellular compartments using the Ingenuity Pathway Analysis (IPA) bioprofiler tool. The twofold enriched hBM-MSC-sEV protein dataset organized into d significantly upregulated cellular and molecular functions and e significantly upregulated physiological development and functions using IPA. Y-axis shows the significantly upregulated pathways and the X-axis shows the −log₁₀ p value with a threshold set at 1.30 (−log₁₀ p value) or p value of 0.05. Significantly upregulated pathways were calculated using a right-tailed Fisher’s exact test in IPA