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. 2019 Dec 18;10:401. doi: 10.1186/s13287-019-1516-2

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Functional pathway analysis of plasma membrane proteins from the twofold enriched dataset of hBM-MSC-sEVs. a Functional annotation of plasma membrane proteins from the twofold enriched dataset of hBM-MSC-sEVs showed an increase (activation z-score of ≥ + 2) in those categories: migration of cells, cell movement of leukocytes, invasion of cells, chemotaxis, vasculogenesis, and leukocyte migration. Shown in bold are the common proteins further inquired for the hierarchical network (b) of plasma membrane proteins from the twofold enriched dataset of hBM-MSC-sEVs highlighting the associated activated functions (activation z-score ≥ + 2), such as migration of cells, cell movement of leukocytes, invasion of cells, chemotaxis, vasculogenesis, and leukocyte migration with the NRP1 activated pathways highlighted