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. 2019 Dec 19;12:76. doi: 10.1186/s13072-019-0318-1

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© The Author(s) 2019

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — HOX gene expression was upregulated and H3K27me3 levels were decreased in human anencephaly. a HOX genes were detected with NanoString in the brain tissues from human anencephaly and normal cases. Data are shown as the mean (SD; n = 10). P < 0.05 indicates statistical significance. b Detection of histone H3K27me3 modification in brain tissues from human anencephaly and normal cases by western blotting. Total histone H3 was used as a loading control. Data are shown as the mean (SD; n = 10). c Quantification analysis of the H3K27me3 signal normalized to the H3 signal between human anencephaly and normal cases. d Pearson’s correlation analysis between HOXs expression and H3K27me3 level. P < 0.05 indicates statistical significance