Fig. 6.

Promotion of pancreatic cancer growth by IGF2BP2 via PI3K-Akt signaling pathway activation in vivo. a Representative images of the subcutaneous xenografts of different treatment groups. b Tumor volume curves of different treatment groups. c Tumor weight of different treatment groups. d IHC staining of xenografts of different treatment groups. Scale bar, 50 μm (red line). e Representative images of phosphorylated AKT(S473) staining in human pancreatic cancer tissues and matched nontumor tissues. Scale bar, 50 μm (red line). f Relative expression score of phosphorylated AKT(S473) in pancreatic cancer by IHC. g Positive correlation between the expression level of IGF2BP2 and level of phosphorylated AKT(S473) by IHC in human pancreatic cancer tissues. *P < 0.05, **P < 0.01, and ***P < 0.001. P < 0.05 was considered statistically significant