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. 2019 Dec 18;38:497. doi: 10.1186/s13046-019-1470-y

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Low expression of miR-141 correlates with worse clinical outcome in pancreatic cancer patients. a and b Expression of miR-141 in pancreatic cancer based on GEO datasets. c Survival analysis of miR-141 based on the TCGA dataset. d Survival curves of IGF2BP2^high&miR-141^low, IGF2BP2^high&miR-141^high, IGF2BP2^low&miR-141^low and IGF2BP2^low& miR-141^high groups. The median survival times for each group were 16.36 months, 16.79 months, 22.83 months and undefined, respectively. e Illustration of overexpression of IGF2BP2 by multiple mechanisms activates PI3K-Akt signaling in pancreatic cancer cells. U6 served as an internal reference. Data are presented as the mean ± SD of at least three independent measurements. *P < 0.05, **P < 0.01, and ***P < 0.001. P < 0.05 was considered statistically significant