Table 1.

Plant enzymes functionally characterized and involved in magnoflorine biosynthesis

Enzyme		Source plants	Reference*
Acronyms and/or abbreviations	Name [GeneBank accession number]
TYDC	tyrosine decarboxylase [AAA62346.1|AAA62347.1]	Papaver somniferum	[53]
NCS	(S)-norcoclaurine synthase [BAF45337.1|AAR22502.1]	Coptis japonica Thalictrum flavum	[54] [55]
6OMT	(S)-norcoclaurine 6′-O-methyltransferase [AAQ01669]	Papaver somniferum	[56]
CNMT	(S)-coclaurine N-methyltransferase [BAB71802.1]	Coptis japonica	[57]
NMCH (CYP82B subfamily)	(S)-N-methylcoclaurine 3′-hydroxylase [AC39454.1]	Eschscholzia california	[50]
4OMT	(S)3′-hydroxy N-methylcoclaurine 4′-O-methyltransferase [AAP45313.1|BAB08005.1]	Coptis japonica	[58]
CTS (CYP80G2 subfamily)	(S)-corytuberine synthase [BAF80448.1]	Coptis japonica	[43]
RNMT	reticuline N-methyltransferase [AOR51553.1|AOR51552.1]	Papaver somniferum	[44]

*References mainly correspond to recent reports in which the activity of these enzymes was proved. Additional studies confirm the presence of most of these enzymes in species such as P. somniferum and C. japonica