Table 3. Pharmacokinetic Parameters of EFV, TFV, and FTC after a Single IP Administration to Healthy Female SD Rats.

	EFV		TFV		FTC
parameter	plasma	brain	plasma	brain	plasma	brain
Cmax ± SEM (ng/mL or ng/g)	3246.07 ± 480.54	428.54 ± 33.34	5651.72 ± 672.87	51.06 ± 29.23	6470.33 ± 500.57	591.57 ± 46.28
Tmax (h)	0.25	0.50	0.25	0.25	0.25	0.25
t1/2 (h)	0.60	2.80	0.90	1.89	0.96	0.65
AUC0–t (ng h/mL or ng h/g)	4255.38	1509.14	6807.64	538.50	9796.38	666.53